1-(4-Chlorophenyl)-2,2,2-trifluoroethanol CAS 446-66-2
| CAS No. | 446-66-2 |
| Molecular Formula | C8H6ClF3O |
| Molecular Weight | 210.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 210.58 g/mol gives 1-(4-Chlorophenyl)-2,2,2-trifluoroethanol distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 1-(4-Chlorophenyl)-2,2,2-trifluoroethanol (CAS 446-66-2), a certified reference material (molecular formula C8H6ClF3O, MW 210.58 g/mol) for analytical method development and quality control.
1-(4-Chlorophenyl)-2,2,2-trifluoroethanol (C8H6ClF3O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-(4-Chlorophenyl)-2,2,2-trifluoroethanol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6ClF3O |
| Molecular Weight | 210.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Chlorophenyl Standards
- (R)-1-(3-chlorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 376347-10-3)
- 1-(2-Chlorophenyl)-2,2,2-trifluoroethanol (CAS 251352-64-4)
- 1-(3-Chlorophenyl)-2,2,2-trifluoroethanol (CAS 81577-11-9)
- (E)-4-(3-chlorophenyl)-2-oxobut-3-enoic acid (CAS 1244025-00-0)
- 4-Chlorophenyl sulfofluoridate (CAS 1535-33-7)
- 4-(3-Chlorophenyl)-4-oxo-2-butenoic Acid (CAS 191015-04-0)
- (E)-4-(4-chlorophenyl)-2-oxobut-3-enoic acid (CAS 33185-97-6)
- (E)-4-(4-Chlorophenyl)-2-oxobut-3-enoic acid (CAS 42393-06-6)
Recommended Standards
- 1-(6-Chloropyridin-3-yl)-2,2,2-trifluoroethan-1-amine (CAS 886364-41-6)
- 1-(3-Chloro-5-(trifluoromethyl)phenyl)hydrazine (CAS 96406-91-6)
- 1-(Chloromethyl)-3-(trifluoromethoxy)benzene (CAS 89807-43-2)
- 1-Chloro-2-(2,2,2-trifluoroethoxy)benzene (CAS 84328-68-7)
- n-(3-Iodophenyl)-2,3-dimethylbenzamide (CAS 852665-70-4)
- (E)-N'-[(4-Methylphenyl)methoxy]-N-{thieno[2,3-d]pyrimidin-4-yl}methanimidamide (CAS 477846-32-5)
- 2,2'-(((2-Methoxy-5-(2-(methylamino)ethyl)-1,3-phenylene)bis(methylene))bis(4-methoxy-3,1-phenylene))bis(N-methylethan-1-amine) trihydrochloride (CAS 848035-21-2)
- 5-Nitro-6-phenylpyridin-2-amine (CAS 912772-97-5)
- 1,3-Dibromopropane-d6 (CAS 120404-22-0)
- CFM 1571 Hydrochloride (CAS 1215548-30-3)
- Aranorosin (CAS 117184-53-9)
- 3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoic Acid (CAS 391211-97-5)
- Letrozole Impurity 12 (CAS CATO-C4X-182912)
- Tirzepatide-d7 Ditrifluoroacetate (CAS CATO-CPTD788698)
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