Sunitinib Impurity 1 CAS 37746-78-4
| CAS No. | 37746-78-4 |
| Molecular Formula | C6H9BrO2 |
| Molecular Weight | 193.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sunitinib Impurity 1 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Sunitinib Impurity 1 (CAS 37746-78-4, C6H9BrO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Sunitinib Impurity 1 (C6H9BrO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 193.04 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H9BrO2 |
| Molecular Weight | 193.04 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Br-containing |
Related Sunitinib Standards
- Sunitinib Impurity 12 (CAS CATO-C4X-133312)
- Sunitinib Impurity 14 (CAS 1309935-08-7)
- Sunitinib Impurity 52 (CAS 2199-59-9)
- Sunitinib Impurity 43 (CAS 14352-65-9)
- Sunitinib Impurity 58 (CAS 17106-12-6)
- Sunitinib Impurity 85 (CAS 17106-16-0)
- Sunitinib Impurity 5 (CAS 5434-29-7)
- Sunitinib Impurity 20 (CAS 879274-72-3)
Recommended Standards
- (E)-6-bromohex-4-enoic acid (CAS CATO-C3D-262633)
- 4-[(Isopropylamino)methyl]phenylboronic acid (CAS 1025900-37-1)
- 2-Bromo-3-methylbutenoic acid methyl ester 4627AE 51263-40-2 C6H9BrO2 (CAS 51263-40-2)
- 4-Propylaminomethylphenylboronic acid (CAS 102712-19-6)
- Ketorolac Impurity 19 (CAS CATO-C4X-166919)
- Levocarnitine Impurity 17 (CAS 90866-33-4)
- Tosufloxacin Impurity 64 (CAS CATO-C4X-19764)
- 5-Bromo-N-isopropylpyrimidin-2-amine (CAS 77476-95-0)
- Boc-Gly-Gly-N-[4-(hydroxymethyl)phenyl] (CAS 251459-35-5)
- 3-Cyclopropoxy-5-isopropylisonicotinic acid (CAS 1243378-25-7)
- 3-(2-Methoxyethyl)-2-methyl-2,3,5,6-tetrahydro-4H-2,6-methanobenzo[g][1,3,5]oxadiazocine-4-thione (CAS 702655-67-2)
- (4-Ethoxy-2,6-dimethylphenyl)methanol (CAS 1379225-15-6)
- 4-Carbamoyl-3-methoxybenzoic acid (CAS 773056-89-6)
- Semaglutide impurity 22(OtBu-Ste-γGlu(OtBu)-AEEA-AEEA-OH) (CAS 1118767-16-0)
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