Tenofovir alafenamide impurity 78 CAS 379270-38-9
| CAS No. | 379270-38-9 |
| Molecular Formula | C21H29N6O5P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tenofovir alafenamide impurity 78 (CAS 379270-38-9) is a certified pharmaceutical impurity reference standard with the molecular formula C21H29N6O5PC4H4O4 and a molecular weight of 592.55 g/mol.
Based on its molecular formula C21H29N6O5PC4H4O4, Tenofovir alafenamide impurity 78 contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 592.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tenofovir alafenamide impurity 78 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H29N6O5P C4H4O4 |
| Molecular Weight | 592.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 79 (CAS 102-10-3)
- rac Tenofovir-d6 (CAS 1020719-94-1)
- Tenofovir disoproxil Impurity 142 (CAS 102537-97-3)
- Tenofovir Disoproxil Dimer (CAS 1093279-76-5)
- Tenofovir disoproxil Impurity 6 (CAS 1093279-77-6)
- Tenofovir disoproxil Impurity 28 (CAS 1115-59-9)
- Tenofovir Impurity 59 (CAS 116384-56-6)
- Tenofovir alafenamide impurity 85 (CAS 121149-98-2)
Recommended Standards
- Cefprozil EP Impurity K-Isomer 2 (CAS CATO-C4X-149222)
- Phytomenadione/Vitamin K1 Impurity 129 (CAS 1181-23-3（无手性）)
- Tamsulosin Impurity 42 (CAS 94-71-3)
- Benzyl 3-(benzoyloxy)-4,4-dimethoxypiperidine-1-carboxylate (CAS 1956309-85-5)
- 4-[(2,4-Dichlorophenyl)sulfanyl]-6-(4-methylphenyl)-2-(methylsulfanyl)pyrimidine-5-carbonitrile (CAS 303984-99-8)
- 2-(Cyclohexyloxy)ethan-1-amine (CAS 90226-63-4)
- N-(3-Amino-2-methylphenyl)-2-(4-chlorophenoxy)-acetamide (CAS 953734-47-9)
- 2-(1-Methyl-1H-imidazol-2-yl)phenol (CAS 52755-94-9)
- (cis-1-Benzylpyrrolidine-2,5-diyl)dimethanol (CAS 269077-39-6)
- Semaglutide impurity 24 (CAS CATO-C4X-222624)
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