Tocopherol Impurity 4 CAS 3808-26-2
| CAS No. | 3808-26-2 |
| Molecular Formula | C29H48O2 |
| Molecular Weight | 428.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C29H48O2, Tocopherol Impurity 4 contains a steroid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 428.69 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Tocopherol Impurity 4 (CAS 3808-26-2, C29H48O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tocopherol Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H48O2 |
| Molecular Weight | 428.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Tocopherol Standards
- (2S)-α-Tocopherol (Mixture of Diastereomers) (CAS 1411583-24-8)
- (2R)-α-Tocopherol (Mixture of Diastereomers) (CAS 895518-38-4)
- Tocopherol Impurity 23 (Deshydroxy Tocopherol Quinone) (CAS 75917-94-1)
- Tocopherol impurity 37 (CAS 185672-33-7)
- DL-Tocopherol (CAS 2074-53-5)
- Tocopherol Impurity 25 (CAS 69371-91-1)
- Tocopherol Impurity 32 (CAS CATO-C4X-119532)
- b-Tocopherol-d3(major) (CAS 936230-75-0)
Recommended Standards
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- Cholesterol Impurity 39 (CAS 17137-70-1)
- Elagolix Impurity 98 (CAS CATO-C4X-206898)
- Landiolol Impurity 105 (CAS CATO-C4X-2621105)
- Cholecalciferol impurity 24 (CAS 300692-92-6)
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- Methyl 5-chloro-6-isopropoxynicotinate (CAS 1258875-29-4)
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