Cyanocobalamin EP Impurity D(Cyanocobalamin-b-monocarboxylic acid; 32-Carboxycyanocobalamin) CAS 38218-77-8
| CAS No. | 38218-77-8 |
| Molecular Formula | C63H87CoN13O15P |
| Molecular Weight | 1356.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Cyanocobalamin EP Impurity D(Cyanocobalamin-b-monocarboxylic acid; 32-Carboxycyanocobalamin) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Cyanocobalamin EP Impurity D(Cyanocobalamin-b-monocarboxylic acid; 32-Carboxycyanocobalamin) (CAS 38218-77-8, C63H87CoN13O15P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Cyanocobalamin EP Impurity D(Cyanocobalamin-b-monocarboxylic acid; 32-Carboxycyanocobalamin) (C63H87CoN13O15P) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C63H87CoN13O15P |
| Molecular Weight | 1356.37 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 27.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Nitrogen Atoms | 13 |
Related Cyanocobalamin Standards
- Cyanocobalamin EP Impurity B (CAS 26264-28-8)
- Cyanocobalamin /Vitamin B12 Impurity 22 (CAS 38437-93-3)
- Cyanocobalamin /Vitamin B12 Impurity 23 (CAS 38218-55-2)
- Cyanocobalamin Impurity 31 (CAS 121483-62-3)
- Cyanocobalamin Impurity 24 (CAS CATO-C4X-187424)
- Cyanocobalamin Impurity 25 (CAS CATO-C4X-187425)
- Cyanocobalamin Impurity 26 (CAS CATO-C4X-187426)
- Cyanocobalamin EP Impurity E (8-epi-cyanocobalamin) (CAS 41325-63-7)
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