Cyanocobalamin EP Impurity E (8-epi-cyanocobalamin) CAS 41325-63-7
| CAS No. | 41325-63-7 |
| Molecular Formula | C63H88CoN14O14P |
| Molecular Weight | 1355.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Cyanocobalamin EP Impurity E (8-epi-cyanocobalamin) (CAS 41325-63-7, C63H88CoN14O14P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, Cyanocobalamin EP Impurity E (8-epi-cyanocobalamin) is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 1355.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C63H88CoN14O14P |
| Molecular Weight | 1355.37 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 27.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 14 |
Related Cyanocobalamin Standards
- Cyanocobalamin Impurity 31 (CAS 121483-62-3)
- Cyanocobalamin EP Impurity B (CAS 26264-28-8)
- Cyanocobalamin /Vitamin B12 Impurity 22 (CAS 38437-93-3)
- Cyanocobalamin /Vitamin B12 Impurity 23 (CAS 38218-55-2)
- Cyanocobalamin EP Impurity A (CAS 23208-66-4)
- Cyanocobalamin EP Impurity D(Cyanocobalamin-b-monocarboxylic acid; 32-Carboxycyanocobalamin) (CAS 38218-77-8)
- Cyanocobalamin Impurity 24 (CAS CATO-C4X-187424)
- Cyanocobalamin Impurity 25 (CAS CATO-C4X-187425)
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