Cyanocobalamin EP Impurity B CAS 26264-28-8

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.26264-28-8
Molecular FormulaC63H87CoN13O15P
Molecular Weight1356.37 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Cyanocobalamin EP Impurity B CAS 26264-28-8 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cyanocobalamin EP Impurity B.

CATO supplies Cyanocobalamin EP Impurity B (CAS 26264-28-8), a pharmacopoeial impurity reference standard (molecular formula C63H87CoN13O15P, MW 1356.37 g/mol) used for the identification and quantification of trace impurities in APIs.

Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, Cyanocobalamin EP Impurity B is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 1356.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Cyanocobalamin EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC63H87CoN13O15P
Molecular Weight1356.37 g/mol
Purity>90%
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)27.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1964
Nitrogen Atoms13

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