Berberine Impurity 2 CAS 38691-95-1
| CAS No. | 38691-95-1 |
| Molecular Formula | C19H16NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Berberine Impurity 2 (CAS 38691-95-1) is a certified pharmaceutical impurity reference standard with the molecular formula C19H16NO4Cl and a molecular weight of 357.79 g/mol.
Structurally, Berberine Impurity 2 (C19H16NO4Cl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 357.79 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Berberine Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H16NO4 Cl |
| Molecular Weight | 357.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Berberine Standards
- Berberine Impurity 33 (CAS 100101-07-3)
- Berberine Impurity 15 Chloride (CAS 1186107-72-1)
- Berberine Chloride hydrate (CAS 141433-60-5)
- Berberine Impurity 31 (CAS 17388-19-1)
- Berberine Impurity 14 (CAS 2043361-62-0)
- Berberine (CAS 2086-83-1)
- Berberine Impurity 16 Chloride (CAS 2363741-22-2)
- Berberine Impurity 29 (CAS 2375597-30-9)
Recommended Standards
- Nifedipine Impurity 36 (CAS CATO-C4X-141036)
- Clindamycin Phosphate EP Impurity J (CAS 1309349-64-1)
- Citalopram Impurity 17 (CAS 1187671-15-3)
- Aluminum phthalocyanine hydroxide (CAS 15554-15-1)
- 1,2-Bis(trifluoromethyl)-3,4-dichlorobenzene (CAS 1221272-78-1)
- N-(2-Aminoethyl)-3-(trifluoromethyl)aniline hydrochloride (CAS 1203579-21-8)
- 5-Chloro-4-{[(4-methoxyphenyl)methoxy]methyl}-1-methyl-3-phenyl-1H-pyrazole (CAS 318248-46-3)
- 4-Chloro-7-isopropyl-N-propyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine (CAS 1380343-11-2)
- S-(1, 2, 2-Trichlorovinyl)-Glutathione (CAS 111574-85-7)
- Mast Cell Degranulating Peptide (CAS 83856-13-7)
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