2-(2,2,2-trifluoroacetyl)cyclohexan-1-one CAS 387-89-3
| CAS No. | 387-89-3 |
| Molecular Formula | C8H9F3O2 |
| Molecular Weight | 194.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(2,2,2-trifluoroacetyl)cyclohexan-1-one (CAS 387-89-3), molecular formula C8H9F3O2 and molecular weight 194.15 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 2-(2,2,2-trifluoroacetyl)cyclohexan-1-one is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 194.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-(2,2,2-trifluoroacetyl)cyclohexan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9F3O2 |
| Molecular Weight | 194.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related trifluoroacetyl Standards
- 1-Methyl-3-(2,2,2-trifluoroacetyl)pyrrolidin-2-one (CAS 107470-28-0)
- 1-(2,2,2-Trifluoroacetyl)pyrrolidine-2-carbaldehyde (CAS 245051-66-5)
- 1-(Trifluoroacetyl)-4-piperidinone (CAS 65220-86-2)
- 3-(2,2,2-Trifluoroacetyl)dihydro-2H-pyran-4(3H)-one (CAS 158351-87-2)
- A-trifluoroacetyl-d-valerolactone (CAS 183279-74-5)
- 4-(2,2,2-Trifluoroacetyl)piperazin-2-one (CAS 1254073-73-8)
- 2-(2,2,2-trifluoroacetyl)bicyclo[3.1.0]hexan-3-one (CAS 1417982-75-2)
- 3-(2,2,2-Trifluoroacetyl)bicyclo[3.1.0]hexan-2-one (CAS 1417985-08-0)
Recommended Standards
- 1-[1-(4-Amino-1,2,5-oxadiazol-3-yl)-1H-1,2,3-triazol-4-yl]ethanone (CAS 447409-41-8)
- 2-(2-Cyanamido-4-hydroxypyrimidin-5-yl)acetic acid hydrochloride (CAS 91912-12-8)
- 1-(7-Oxabicyclo[2.2.1]heptan-2-yl)-2,2,2-trifluoroethan-1-one (CAS 2167978-69-8)
- 2-(6-Oxo-1,6-dihydro-9H-purin-9-yl)acetic acid (CAS 6298-53-9)
- 3-Chloro-5-fluorobenzeneboronic acid pinacol ester, 97% (CAS 1245524-02-0)
- N-[2-[(2,3-Difluorobenzyl)thio]-6-[[(2R,3S)-3,4-dihydroxy-2-butyl]oxy]-4-pyrimidinyl]azetidine-1-sulfonamide (CAS 878385-84-3)
- 1-(1,2-Dihydroquinoxalin-2-yl)ethanol (CAS 111289-53-3)
- 16807-37-7 2-Mercapto-5-methoxybenzoic Acid 5-Methoxythiosalicylic Acid 6-Mercapto-m-anisic Acid NSC 372684 (CAS 16807-37-7)
- N,N-dimethylpyrrolidine-3-sulfonamide hydrochloride (CAS 1825309-05-4)
- Ethyl 2,2-dimethyl-4-(2-naphthyl)-4-oxobutyrate (CAS 898753-71-4)
- 4-amino-2-vinylpyridine (CAS 102000-57-7)
- 3,5-Diethyl 6-amino-1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-2-oxo-1,2-dihydropyridine-3,5-dicarboxylate (CAS 551921-17-6)
- 3'-Chloro-4-(piperidin-1-yl)-5'-(trifluoromethyl)-3,6-dihydro-2H-1,2'-bipyridine (CAS 306977-24-2)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
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