1-(Trifluoroacetyl)-4-piperidinone CAS 65220-86-2
| CAS No. | 65220-86-2 |
| Molecular Formula | C7H8F3NO2 |
| Molecular Weight | 195.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies 1-(Trifluoroacetyl)-4-piperidinone (CAS 65220-86-2), a certified reference material (molecular formula C7H8F3NO2, MW 195.14 g/mol) for analytical method development and quality control.
The molecular framework of 1-(Trifluoroacetyl)-4-piperidinone (C7H8F3NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8F3NO2 |
| Molecular Weight | 195.14 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoroacetyl Standards
- 1-Methyl-3-(2,2,2-trifluoroacetyl)pyrrolidin-2-one (CAS 107470-28-0)
- 1-(2,2,2-Trifluoroacetyl)pyrrolidine-2-carbaldehyde (CAS 245051-66-5)
- 3-(2,2,2-Trifluoroacetyl)dihydro-2H-pyran-4(3H)-one (CAS 158351-87-2)
- A-trifluoroacetyl-d-valerolactone (CAS 183279-74-5)
- 2-(2,2,2-trifluoroacetyl)cyclohexan-1-one (CAS 387-89-3)
- 4-(2,2,2-Trifluoroacetyl)piperazin-2-one (CAS 1254073-73-8)
- 1-(2,2,2-trifluoroacetyl)azetidine-3-carboxylic acid (CAS 1001026-41-0)
- 2-(2,2,2-trifluoroacetyl)bicyclo[3.1.0]hexan-3-one (CAS 1417982-75-2)
Recommended Standards
- 1-Bromooctane-1,1-d2 (CAS 86423-34-9)
- (1S)-1-[4-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]ethanol (CAS 2833707-09-6)
- 3-(4-Methyl-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazole-5-carboxamide (CAS 890096-09-0)
- N-hydroxy-3-(trifluoromethyl)bicyclo[1.1.1]pentane-1-carboxamide (CAS 1862703-41-0)
- 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[2-(4-nitrophenyl)ethyl]-Isoquinoline (CAS 82925-01-7)
- 6-Chloro-1-(3,5-difluorophenyl)-1H-indole-3-carboxylic acid (CAS 921195-18-8)
- Methyl 4-chloro-1-(2-fluoroethyl)-1H-pyrazole-5-carboxylate (CAS 1429417-55-9)
- 6-Chloro-1-phenyl-1h,4h,5h-pyrazolo[3,4-d]pyrimidine (CAS 130024-05-4)
- 1,3-Diethyl 2-(2-Azidoethyl)propanedioate (CAS 131325-86-5)
- 3,5-Dichloropyridin-4(1H)-one (CAS 17228-70-5)
- Methylcyclohexane-d14 (reagent grade) (CAS 10120-28-2)
- cis-4-Hydroxy-L-proline Hydrochloride (CAS 441067-49-8)
- (3AR,6aS)-2-benzyl-3a,6a-difluorooctahydropyrrolo[3,4-c]pyrrole (CAS 2086686-21-5)
- Insulin Glargine (CAS 160337-95-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com