Amlodipine Impurity 25 CAS 3891-07-4
| CAS No. | 3891-07-4 |
| Molecular Formula | C10H9NO3 |
| Molecular Weight | 191.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Amlodipine Impurity 25 is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Amlodipine Impurity 25 (CAS 3891-07-4, C10H9NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Amlodipine Impurity 25 (C10H9NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 191.18 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Amlodipine Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9NO3 |
| Molecular Weight | 191.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Amlodipine Standards
- Amlodipine Impurity 89 (CAS CATO-C4X-109589)
- Amlodipine Impurity N12 (CAS 88-66-4)
- Amlodipine Impurity N1 (CAS 58509-24-3)
- Amlodipine Impurity 39 (CAS 5183-78-8)
- Amlodipine Impurity 88 (CAS CATO-C4X-109588)
- Amlodipine Impurity 54 (CAS 136744-85-9)
- Amlodipine Impurity N18 (CAS 72569-97-2)
- Amlodipine Impurity N11 (CAS 31259-91-3)
Recommended Standards
- 3-Ethyl-2h-1,3-Benzoxazine-2,4(3h)-Dione (CAS 2038-01-9)
- Nicardipine Impurity 26 (CAS 30625-99-1)
- Methyl Oxindole-5-carboxylate (CAS 199328-10-4)
- Zonisamide Impurity 16 (CAS 59899-89-7)
- Neostigmine impurity 48 Metilsulfate (CAS CATO-C4X-204248)
- Tenofovir alafenamide Impurity 31 (CAS CATO-C4X-179731)
- Rifapentine impurity 18 (CAS CATO-C4X-195918)
- (S)-4,7-Difluoro-2,3-dihydro-1H-inden-1-amine hydrochloride (CAS 2135344-97-5)
- 2-[3-(difluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 627525-89-7)
- Eldecalcitol Impurity 3 (CAS 861996-34-1)
- 5-(2-Methoxyphenyl)-1,3,4-oxadiazole-2-carboxylic acid (CAS 944907-21-5)
- 5,6-dichloro-3-imino-2,3-dihydro-1H-isoindol-1-one (CAS 35190-38-6)
- N-allyl-2-isopropyl-6-methylpyrimidin-4-amine (CAS 383146-01-8)
- Peptide YY (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 81858-94-8)
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