Amlodipine Impurity N12 CAS 88-66-4
| CAS No. | 88-66-4 |
| Molecular Formula | C7H5Cl3 |
| Molecular Weight | 195.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Amlodipine Impurity N12.
Amlodipine Impurity N12 (CAS 88-66-4) is a certified pharmaceutical impurity reference standard with the molecular formula C7H5Cl3 and a molecular weight of 195.47 g/mol.
Amlodipine Impurity N12 (C7H5Cl3) contains chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Amlodipine Impurity N12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5Cl3 |
| Molecular Weight | 195.47 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Amlodipine Standards
- Amlodipine Impurity 25 (CAS 3891-07-4)
- Amlodipine Impurity 89 (CAS CATO-C4X-109589)
- Amlodipine Impurity N1 (CAS 58509-24-3)
- Amlodipine Impurity 39 (CAS 5183-78-8)
- Amlodipine Impurity 88 (CAS CATO-C4X-109588)
- Amlodipine Impurity N11 (CAS 31259-91-3)
- Amlodipine Impurity 103 (CAS 53901-54-5)
- Amlodipine Impurity 54 (CAS 136744-85-9)
Recommended Standards
- 2,3,5-Trichlorotoluene (CAS 56961-86-5)
- 2-Bromochlorobenzene-d4 (CAS 1219795-51-3)
- 2,4,5-Trichlorotoluene (CAS 6639-30-1)
- 4-Bromochlorobenzene-d4 (CAS 134415-42-2)
- Topiroxostat Impurity 78 (CAS CATO-C4X-105578)
- Amiodarone Impurity 45 (CAS CATO-C4X-142545)
- Atropine Impurity 18 (CAS 532-24-1)
- 3-(4-Bromo-5-methyl-1H-pyrazol-1-yl)propanoic acid 3930AE 456396-56-8 C7H9BrN2O2 (CAS 456396-56-8)
- 1-(2-Oxopropyl)piperidine-4-carboxylic acid (CAS 1397293-42-3)
- 4-(trifluoromethyl)dihydro-2H-pyran-2,6(3H)-dione (CAS 4759-65-3)
- 2-AMINO-2-(6-METHYLPYRIDIN-3-YL)ETHAN-1-OL 2HCL (CAS 2177259-11-7)
- 4-chloro-1-(methoxymethyl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (CAS 958230-31-4)
- 1310405-24-3 tert-Butyl 4-{2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]ethyl}piperidine-1-carboxylate (CAS 1310405-24-3)
- Insulin Degludec Impurity 12 (CAS CATO-C4X-215712)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com