Ezetimibe Impurity 72 CAS CATO-C4X-109872
| CAS No. | CATO-C4X-109872 |
| Molecular Formula | C24H19F2NO3 |
| Molecular Weight | 407.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ezetimibe Impurity 72 (CAS CATO-C4X-109872, C24H19F2NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ezetimibe Impurity 72 (C24H19F2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ezetimibe Impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H19F2NO3 |
| Molecular Weight | 407.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe ketone (CAS 191330-56-0)
- Ezetimibe Impurity 33 (CAS 1700622-07-6)
- Ezetimibe Impurity ((S)-4-Phenyloxazolidin-2-one) Sodium salt (CAS 200067-49-8)
- Ezetimibe (CAS 163222-33-1)
- Ezetimibe meta-Fluorobenzene Isomer (CAS CATO-C4X-1098127)
- Ezetimibe Lactone Impurity 128 (CAS CATO-C4X-1098128)
- Ezetimibe Impurity 17(SCH59566) (CAS 1296129-15-1)
- Ezetimibe Ring-Opening Dehydrate Impurity (CAS 1292292-63-7)
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