2-Chloro-3-(trifluoromethyl)benzoic Acid CAS 39226-97-6
| CAS No. | 39226-97-6 |
| Molecular Formula | C8H4ClF3O2 |
| Molecular Weight | 224.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Chloro-3-(trifluoromethyl)benzoic Acid (C8H4ClF3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies 2-Chloro-3-(trifluoromethyl)benzoic Acid (CAS 39226-97-6), a certified reference material (molecular formula C8H4ClF3O2, MW 224.56 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 2-Chloro-3-(trifluoromethyl)benzoic Acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3O2 |
| Molecular Weight | 224.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-(3-Chloro-4-fluorophenyl)-2,2-difluoroacetic acid (CAS 1027514-19-7)
- 2-Chloro-4-(trifluoromethoxy)benzaldehyde (CAS 1079351-20-4)
- 5-Chloro-2-(trifluoromethoxy)benzaldehyde (CAS 1092461-15-8)
- 3-Chloro-4-(trifluoromethyl)benzoic Acid (CAS 115754-20-6)
- Methyl 3-chloro-2,4,5-trifluorobenzoate (CAS 1214375-02-6)
- 4-Chloro-2-(trifluoromethoxy)benzaldehyde (CAS 1261442-48-1)
- 3-Chloro-2-(trifluoromethoxy)benzaldehyde (CAS 1261498-32-1)
- 2-Chloro-6-(trifluoromethoxy)benzaldehyde (CAS 1261822-56-3)
Recommended Standards
- 2-Chloro-3-(trifluoromethoxy)benzaldehyde (CAS 937069-71-1)
- 2-Chloro-4-(trifluoromethyl)benzoic acid (CAS 23228-45-7)
- 2,3,5-Trifluoro-4-methoxybenzoyl chloride (CAS 501701-44-6)
- 2-Chloro-5-(trifluoromethoxy)benzaldehyde (CAS 468075-02-7)
- 2-(2-Chlorophenyl)-5-(trifluoromethyl)-2H-1,2,3-triazole-4-carboxylic acid (CAS 1431727-78-4)
- 6-cyclopropyl-2-methylpyridine-3-carboxylic acid hydrochloride (CAS 1820686-11-0)
- 2-Chloro-1-iodo-4-isopropoxybenzene (CAS 1369830-17-0)
- 1-(Pyrimidin-2-yloxy)propan-2-amine (CAS 167087-51-6)
- 2,6-Diphenylbenzo[1,2-b:4,5-b']difuran (CAS 5379-77-1)
- Benzyl (6-chloro-8-oxo-7H-purin-9(8H)-yl)carbamate (CAS 15206-32-3)
- 1-pyrrolidin-2-ylcyclopropanol (CAS 1784640-67-0)
- N,6-Dimethylpyrazine-2-carboxamide (CAS 90185-89-0)
- tert-Butyl 1H-pyrrolo[2,3-b]pyridin-6-ylcarbamate (CAS 1346447-43-5)
- β-Asp9-Tirzepatide (CAS CATO-CPTD788931)
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