Epalrestat impurity 33 CAS 39486-57-2
| CAS No. | 39486-57-2 |
| Molecular Formula | C5H6N2O2S2 |
| Molecular Weight | 190.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Epalrestat impurity 33 (CAS 39486-57-2) is a certified pharmaceutical impurity reference standard with the molecular formula C5H6N2O2S2 and a molecular weight of 190.24 g/mol.
Structurally, Epalrestat impurity 33 (C5H6N2O2S2) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 190.24 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C5H6N2O2S2 |
| Molecular Weight | 190.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Epalrestat Standards
- Epalrestat Impurity 12 (CAS 109801-00-5)
- Epalrestat Impurity 21 (CAS 5718-83-2)
- Epalrestat impurity 28 (CAS 179027-75-9)
- Epalrestat Impurity 54 (CAS 1408072-62-7)
- Epalrestat impurity 32 (CAS CATO-C4X-223632)
- Epalrestat Impurity 19 (CAS 149789-77-5)
- Epalrestat Impurity 14 (CAS 31061-24-2)
- Epalrestat Impurity 61 (CAS CATO-C4X-223661)
Recommended Standards
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- Nicotinamide impurity 27 (CAS CATO-C4X-200027)
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- Citicoline Impurity 8 (CAS 3036-18-8)
- 2-[1-(5-bromo-2-methylphenyl)-n-methylformamido]acetic acid (CAS 1482137-44-9)
- 2'-(4-Chlorophenyl)-5,5'-dimethyl-2-phenyl-1',2'-dihydro-2H,3'H-[3,4'-bipyrazol]-3'-one (CAS 245039-32-1)
- N,N-diphenyl-[1,1-biphenyl]-4-amine (CAS 4432-94-4)
- 1-Benzyl-4-cyano-4-(isopropylamino)-piperidine hydrate (CAS 194798-48-6)
- 4-(4-tert-Butylphenoxy)-2-phenylquinazoline (CAS 866155-20-6)
- 3-Bromo-6-methoxy-2-methyl-2H-indazole (CAS 1781109-38-3)
- D-[γ-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226254)
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