Tolvaptan Impurity 38 CAS 3951-89-1
| CAS No. | 3951-89-1 |
| Molecular Formula | C10H10BrNO |
| Molecular Weight | 240.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Tolvaptan Impurity 38 (C10H10BrNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Tolvaptan Impurity 38 (CAS 3951-89-1) is a certified pharmaceutical impurity reference standard with the molecular formula C10H10BrNO and a molecular weight of 240.10 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tolvaptan Impurity 38 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H10BrNO |
| Molecular Weight | 240.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Tolvaptan Standards
- Tolvaptan Impurity 107 (CAS 2735310-65-1)
- Tolvaptan Impurity 74 (CAS CATO-C4X-195574)
- Tolvaptan Impurity 77 (CAS CATO-C4X-195577)
- Tolvaptan Impurity 106 (CAS 792931-77-2)
- Tolvaptan Impurity 37 (CAS 607-86-3)
- Tolvaptan Impurity 86 (CAS 108166-22-9)
- Tolvaptan Impurity 119 (CAS CATO-C4X-1955119)
- Tolvaptan Impurity 5 (CAS CATO-C4X-19555)
Recommended Standards
- rel-Ethyl (1R,2R)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropane-1-carboxylate (CAS 2135443-03-5)
- Methyltin Trichloride (CAS 993-16-8)
- N-allyl-4-bromobenzamide (CAS 39887-27-9)
- (2,6-Dichlorophenyl)methanesulfonamide (CAS 103482-25-3)
- Acyclovir EP Impurity P (CAS 23169-33-7)
- Rizatriptan impurity 16 (CAS CATO-C4X-175216)
- Solriamfetol Impurity 13 (CAS CATO-C4X-256313)
- Ethyl 4-(aminomethyl)-1H-imidazole-5-carboxylate dihydrochloride (CAS 2138039-31-1)
- 5-((3-(4-Isobutoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-(thiophen-2-yl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (CAS 623935-25-1)
- 3-Aminoquinoline-2-carboxylic acid (CAS 887245-74-1)
- Fingolimod Impurity 16 (CAS 1404433-87-9)
- 1-(4-Iodophenyl)-2-(isobutylthio)ethan-1-one (CAS 1152848-78-6)
- Amodiaquine Impurity 15 (CAS 81099-86-7)
- Des-Leu14-Tirzepatide (CAS CATO-CPTD788959)
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