Losartan Impurity 22 CAS 39739-46-3
| CAS No. | 39739-46-3 |
| Molecular Formula | C6H13NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 151.63 g/mol gives Losartan Impurity 22 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Losartan Impurity 22 (CAS 39739-46-3, C6H13NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Losartan Impurity 22 (C6H13NOHCl) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Losartan Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H13NO HCl |
| Molecular Weight | 151.63 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Losartan Standards
Recommended Standards
- Palbociclib Impurity 46 (CAS 1244949-62-9)
- Cyclopentolate Hydrochloride EP Impurity C (CAS 113079-81-5)
- Warfarin impurity 11 (CAS CATO-C4X-17811)
- 4-(2-Naphthyl)aniline (CAS 209848-36-2)
- Methyl 3-{[(4-chlorophenyl)carbamoyl]amino}-4-methylthiophene-2-carboxylate (CAS 1330750-57-6)
- (6-Chloro-4-(difluoromethyl)-5-(trifluoromethyl)pyridin-2-yl)methanol (CAS 1807027-96-8)
- 1,4-Bis(pentafluorothio)benzene (CAS 1219501-58-2)
- 1-(Tetrahydro-2H-pyran-3-carbonyl)azetidine-3-carboxylic acid (CAS 1344061-95-5)
- 1-(3-Chloro-2-methylphenyl)-3-methylbutan-1-one (CAS 1267667-73-1)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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