Losartan Impurity 15 CAS 114772-55-3
| CAS No. | 114772-55-3 |
| Molecular Formula | C22H22ClN3O |
| Molecular Weight | 379.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Losartan Impurity 15 (CAS 114772-55-3, C22H22ClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Losartan Impurity 15 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 379.88 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H22ClN3O |
| Molecular Weight | 379.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Losartan Standards
- Losartan Impurity 29 (CAS 2204369-11-7)
- Losartan Impurity 51 (CAS CATO-C4X-168351)
- Losartan Impurity 61 (CAS CATO-C4X-168361)
- Losartan Impurity 28 (CAS 124750-67-0)
- Losartan Impurity 57 (CAS C4X-13305)
- Losartan Impurity N2 (CAS 1351793-76-4)
- Losartan Impurity 37 (CAS CATO-C4X-168337)
- Losartan Impurity 49 (CAS CATO-C4X-168349)
Recommended Standards
- Zinc trisodium DTPA (CAS 26466-77-3)
- tert-butyl N-{1-[4-(4-chlorophenyl)piperazine-1-carbonyl]cyclopropyl}carbamate (CAS 1989672-33-4)
- N-(4-Butylphenyl)-3-(5-(2-chlorophenyl)furan-2-yl)acrylamide (CAS 853348-22-8)
- Hydroxychloroquine Impurity 40 (CAS CATO-C4X-183540)
- Cefovecin Impurity 5 (CAS CATO-C4X-30355)
- Salbutamol EP Impurity A(Trifluoroacetic Acid) (CAS CATO-C4X-117649)
- Norepinephrine Impurity 35 (CAS 5874-97-5)
- 2-Chloro-N-(4-fluoro-3-methylphenyl)benzamide (CAS 454470-44-1)
- 2-Chloro-N-(1,1-dioxo-1λ6-thiolan-3-yl)-N-(oxolan-2-ylmethyl)acetamide (CAS 852399-83-8)
- 2,4,6-Trimethyl-N-(2-(pyridin-3-yl)pyrimidin-4-yl)benzenesulfonamide (CAS 439108-35-7)
- Parathyroid Hormone (1-38), human (CAS 104218-12-4)
- 4-Amino-N,3-dimethylbenzamide hydrochloride (CAS 1269394-46-8)
- Cyclopentyl(3,4-difluorophenyl)methanol (CAS 1183625-32-2)
- Semaglutide impurity 193 (CAS CATO-C4X-2226193)
Why CATO?
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