4-Bromo-4-fluorobiphenyl CAS 398-21-0
| CAS No. | 398-21-0 |
| Molecular Formula | C12H8BrF |
| Molecular Weight | 251.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Bromo-4-fluorobiphenyl is closely related to fluorine/bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-Bromo-4-fluorobiphenyl (CAS 398-21-0), a certified reference material (molecular formula C12H8BrF, MW 251.09 g/mol) for analytical method development and quality control.
Structurally, 4-Bromo-4-fluorobiphenyl (C12H8BrF) contains fluorine/bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 251.09 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Bromo-4-fluorobiphenyl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8BrF |
| Molecular Weight | 251.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 1-Bromo-3-(4-fluorophenyl)benzene (CAS 10540-35-9)
- 2-Bromo-2'-fluoro-biphenyl (CAS 1554-05-8)
- 5-Bromo-2-fluorobiphenyl (CAS 1809168-63-5)
- 1-Bromo-4-(2-fluorophenyl)benzene (CAS 40641-63-2)
- 2-Bromo-1-(1-(fluoromethyl)-2-oxabicyclo[2.2.1]heptan-4-yl)ethan-1-one (CAS 2763750-95-2)
- 2-Bromo-4'-fluoro-1,1'-biphenyl (CAS 89346-54-3)
- 3-Bromo-3'-fluoro-1,1'-biphenyl (CAS 844856-60-6)
- 3-Bromo-4-fluoro-1,1'-biphenyl (CAS 306935-88-6)
Recommended Standards
- 4'-Bromo-3-fluoro-1,1'-biphenyl (CAS 40641-65-4)
- 4-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (CAS 944401-63-2)
- 4-(2-Morpholinoethoxy)phenylboronic Acid (CAS 279262-19-0)
- 4-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (CAS 2304635-50-3)
- (S)-2-Amino-3-(isoxazol-3-yl)propanoic acid (CAS 189215-63-2)
- N-(2-Nitrophenyl)-3-(5-(3-nitrophenyl)furan-2-yl)propanamide (CAS 853329-63-2)
- N-(oct-7-en-1-yl)thietan-3-amine (CAS 1865108-97-9)
- 6-Ethoxy-2,2-dimethyl-1,2-dihydroquinoline (CAS 287736-48-5)
- 6-Chloro-2-phenylbenzoic acid (CAS 97027-46-8)
- (1R,2R)-2-(3-fluoro-5-(trifluoromethyl)phenyl)cyclopropane-1-carboxylic acid (CAS 2227793-92-0)
- 2,5-Bis(trifluoromethyl)benzenesulfonyl Chloride (CAS 351003-22-0)
- Ethyl 5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole-2-carboxylate (CAS 720702-68-1)
- tert-Butyl 4-[2-(4-methoxyphenyl)-2-oxoethyl]piperazine-1-carboxylate (CAS 664362-19-0)
- Bradykinin-Like Neuropeptide (Aplysia californica) (H-1654.0001) (CAS 165174-60-7)
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