Palbociclib Impurity 1 CAS 39856-50-3
| CAS No. | 39856-50-3 |
| Molecular Formula | C5H3BrN2O2 |
| Molecular Weight | 202.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 202.99 g/mol gives Palbociclib Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Palbociclib Impurity 1 (CAS 39856-50-3, C5H3BrN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Palbociclib Impurity 1 (C5H3BrN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3BrN2O2 |
| Molecular Weight | 202.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Palbociclib Standards
- Palbociclib Impurity 30 (CAS 909712-10-3)
- Palbociclib Impurity 172 (CAS CATO-C4X-1125172)
- Palbociclib Impurity 43 (CAS 51534-82-8)
- Palbociclib Impurity 44 (CAS 82205-58-1)
- Palbociclib Impurity 149 (CAS CATO-C4X-1125149)
- Palbociclib Impurity 82 (CAS 1566082-34-5)
- Palbociclib Impurity 83 (CAS 1211541-02-4)
- Palbociclib Impurity 97 (CAS 775288-71-6)
Recommended Standards
- 2-Bromo-6-nitropyridine (CAS 21203-78-1)
- 6-bromopyridazine-3-carboxylic acid (CAS 65202-51-9)
- (8-Methoxyquinolin-5-yl)boronic acid (CAS 1025735-47-0)
- 5-Bromopyrimidine-2-carboxylic Acid (CAS 37131-87-6)
- Dobutamine Impurity 46 (CAS CATO-C4X-129846)
- Rivastigmine Impurity 14 (CAS 1346242-31-6)
- Upadacitinib Impurity 178 Formate (CAS CATO-C4X-2405178)
- 4-Bromo-5-fluorobenzofuran (CAS 286836-29-1)
- Edoxaban Impurity 73 (CAS 365998-33-0)
- 5-Bromopent-2-ene (CAS 51952-42-2)
- IPI-926 Hydrochloride (CAS 1169829-40-6)
- 6-(3,4-Dimethoxyphenyl)-7-(2-fluorophenyl)-7,12-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine (CAS 799831-42-8)
- 3-fluoro-4-hydrazinylpyridine dihydrochloride (CAS 1955506-84-9)
- TRAF6 Peptide trifluoroacetate salt (CAS 852805-92-6)
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