Palbociclib Impurity 44 CAS 82205-58-1
| CAS No. | 82205-58-1 |
| Molecular Formula | C9H12N4O2 |
| Molecular Weight | 208.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 208.22 g/mol gives Palbociclib Impurity 44 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Palbociclib Impurity 44 (CAS 82205-58-1) is a certified pharmaceutical impurity reference standard with the molecular formula C9H12N4O2 and a molecular weight of 208.22 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Palbociclib Impurity 44 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 208.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Palbociclib Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H12N4O2 |
| Molecular Weight | 208.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Nitrogen Atoms | 4 |
Related Palbociclib Standards
- Palbociclib Impurity 149 (CAS CATO-C4X-1125149)
- Palbociclib Impurity 82 (CAS 1566082-34-5)
- Palbociclib Impurity 83 (CAS 1211541-02-4)
- Palbociclib Impurity 97 (CAS 775288-71-6)
- Palbociclib Impurity 118 (CAS 844843-37-4)
- Palbociclib Impurity 43 (CAS 51534-82-8)
- Palbociclib Impurity 172 (CAS CATO-C4X-1125172)
- Palbociclib Impurity 1 (CAS 39856-50-3)
Recommended Standards
- NSN-Dimer (CAS 7521-27-9)
- tert-Butyl (4-cyano-1H-imidazol-5-yl)carbamate (CAS 500024-61-3)
- N-Ethyl-2-isonicotinoylhydrazine-1-carboxamide (CAS 6266-82-6)
- Tert-butyl (4-cyano-1h-pyrazol-3-yl)carbamate (CAS 500024-60-2)
- Ertugliflozin impurity 10 (CAS 1689522-89-1)
- Relebactam Impurity 93 (CAS 2650115-54-9)
- Canagliflozin Impurity 64 (CAS CATO-C4X-112364)
- B-(4-Chloro-2-fluoro-6-hydroxyphenyl)boronic acid (CAS 2470930-46-0)
- 2-(Benzo[d]oxazol-2(3H)-ylidene)-2-(phenylsulfonyl)acetonitrile (CAS 58092-41-4)
- 4-(Thien-2-ylmethyl)benzoyl Chloride (CAS 1151512-19-4)
- 7-Fluoroquinazolin-4(3H)-one (CAS 16499-57-3)
- 3-Bromo-5-ethylthiophene-2-carbonitrile (CAS 2092741-55-2)
- (2-methoxyphenyl)(phenyl)methanol (CAS 22788-49-4)
- [2-31]-Semaglutide C (x TFA Salt) (CAS CATO-C4X-2226118)
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