Palbociclib Impurity 30 CAS 909712-10-3
| CAS No. | 909712-10-3 |
| Molecular Formula | C5H3BrN2O2 |
| Molecular Weight | 202.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 202.99 g/mol gives Palbociclib Impurity 30 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Palbociclib Impurity 30 (CAS 909712-10-3, C5H3BrN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Palbociclib Impurity 30 (C5H3BrN2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3BrN2O2 |
| Molecular Weight | 202.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Palbociclib Standards
- Palbociclib Impurity 1 (CAS 39856-50-3)
- Palbociclib Impurity 172 (CAS CATO-C4X-1125172)
- Palbociclib Impurity 43 (CAS 51534-82-8)
- Palbociclib Impurity 44 (CAS 82205-58-1)
- Palbociclib Impurity 149 (CAS CATO-C4X-1125149)
- Palbociclib Impurity 82 (CAS 1566082-34-5)
- Palbociclib Impurity 83 (CAS 1211541-02-4)
- Palbociclib Impurity 97 (CAS 775288-71-6)
Recommended Standards
- (8-Methoxyquinolin-5-yl)boronic acid (CAS 1025735-47-0)
- 2-Bromo-6-nitropyridine (CAS 21203-78-1)
- (8-Methoxyquinolin-7-yl)boronic acid (CAS 1093231-09-4)
- 6-bromopyridazine-3-carboxylic acid (CAS 65202-51-9)
- Etoposide EP Impurity O (CAS 260974-95-6)
- Nilotinib Impurity 11 (CAS CATO-C4X-125611)
- Norfloxacin EP Impurity E (CAS 75001-85-3)
- Methyl 2-Bromo-6-(trifluoromethyl)nicotinate (CAS 144740-56-7)
- (3-Ethyl-1-methylcyclohexyl)methanamine (CAS 1498788-81-0)
- 2-(2-((2-Aminoethyl)amino)ethyl)-3',6'-bis(diethylamino)spiro[isoindoline-1,9'-xanthen]-3-one (CAS 1005459-81-3)
- Sumatriptan-D6 (CAS 1020764-38-8)
- 5-Bromo-2-nitrobenzoyl chloride (CAS 22908-25-4)
- Ethyl 4-(2-(2,6-dichloroisonicotinoyl)hydrazinyl)-2-(trifluoromethyl)pyrimidine-5-carboxylate (CAS 264225-78-7)
- Insulin Degludec Impurity 12 (CAS CATO-C4X-215712)
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