Methyldopa EP Impurity C CAS 39948-18-0
| CAS No. | 39948-18-0 |
| Molecular Formula | C12H17NO4 |
| Molecular Weight | 239.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 239.27 g/mol gives Methyldopa EP Impurity C distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Methyldopa EP Impurity C (CAS 39948-18-0), a pharmacopoeial impurity reference standard (molecular formula C12H17NO4, MW 239.27 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Methyldopa EP Impurity C (C12H17NO4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Methyldopa EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H17NO4 |
| Molecular Weight | 239.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 1 |
Related Methyldopa Standards
- Methyldopa EP Impurity A (CAS 6739-31-7)
- Methyldopa Impurity 14 (CAS CATO-C4X-169314)
- DL-Methyldopa (CAS 55-40-3)
- Methyldopa EP Impurity D (CAS 2799-15-7)
- Methyldopa Impurity 15 (CAS CATO-C4X-169315)
- Methyldopa EP Impurity B (Racemate) (CAS 7383-30-4)
- Methyldopa Impurity 13 (CAS 94782-89-5)
- Methyldopa O-Sulfate (Meta) (CAS 72572-96-4)
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Why CATO?
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