Methyldopa EP Impurity A CAS 6739-31-7
| CAS No. | 6739-31-7 |
| Molecular Formula | C11H15NO4 |
| Molecular Weight | 225.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Methyldopa EP Impurity A (C11H15NO4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 225.24 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Methyldopa EP Impurity A (CAS 6739-31-7) is a certified pharmaceutical impurity reference standard with the molecular formula C11H15NO4 and a molecular weight of 225.24 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H15NO4 |
| Molecular Weight | 225.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Methyldopa Standards
- Methyldopa Impurity 14 (CAS CATO-C4X-169314)
- DL-Methyldopa (CAS 55-40-3)
- Methyldopa EP Impurity D (CAS 2799-15-7)
- Methyldopa EP Impurity C (CAS 39948-18-0)
- Methyldopa Impurity 15 (CAS CATO-C4X-169315)
- Methyldopa EP Impurity B (Racemate) (CAS 7383-30-4)
- Methyldopa Impurity 13 (CAS 94782-89-5)
- Methyldopa O-Sulfate (Meta) (CAS 72572-96-4)
Recommended Standards
- Methyl 9H-Carbazole-3-carboxylate (CAS 97931-41-4)
- N-(2-Formylphenyl)benzamide (CAS 33768-43-3)
- Methyl 9H-Carbazole-2-carboxylate (CAS 26000-33-9)
- n-(3,4,5-Trimethoxyphenyl)acetamide (CAS 4304-24-9)
- Fenofibrate EP Impurity E (CAS 42019-07-8)
- Vonoprazan Impurity 37 (CAS 2827733-27-5)
- Tofacitinib Impurity 118 (CAS 1615709-89-1)
- [3,4-Bis(benzyloxy)phenyl]-1,2-ethanediol (CAS 100434-10-4)
- 2-Nitrophenylboronic acid (CAS 5570-19-4)
- (E)-N'-(2,2,2-Trifluoro-1-(2-(3-phenylpropoxy)phenyl)ethylidene)-2-(trifluoromethyl)benzenesulfonohydrazide (CAS 2757122-27-1)
- [1,1,2,2-Tetradeuterio-2-(3-methyl-2-phenylmorpholin-4-yl)ethyl] 2-phenylbutanoate (CAS 1794737-45-3)
- 1-(Morpholinomethyl)-1H-indole-2,3-dione 3-[N-(4-fluorophenyl)hydrazone] (CAS 338391-77-8)
- 1-[4'-(1,3-Dioxolan-2-yl)[1,1'-biphenyl]-3-yl] ethanone (CAS 400743-93-3)
- Neuroendocrine Regulatory Peptide-1 (human) (H-6622.1000) (CAS 954420-50-9)
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