1-(2,6-Dichlorobenzyl)-3'-(4-methoxyphenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione CAS 400081-78-9
| CAS No. | 400081-78-9 |
| Molecular Formula | C24H18Cl2N2O3S |
| Molecular Weight | 485.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2,6-Dichlorobenzyl)-3'-(4-methoxyphenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione.
1-(2,6-Dichlorobenzyl)-3'-(4-methoxyphenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione (CAS 400081-78-9), molecular formula C24H18Cl2N2O3S and molecular weight 485.38 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 1-(2,6-Dichlorobenzyl)-3'-(4-methoxyphenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione (C24H18Cl2N2O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 485.38 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H18Cl2N2O3S |
| Molecular Weight | 485.38 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Dichlorobenzyl Standards
- 3-(((2,4-Dichlorobenzyl)sulfinyl)methyl)-4-ethyl-5-((4-nitrobenzyl)thio)-4H-1,2,4-triazole (CAS 344272-59-9)
- N-((5-((2,4-dichlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)-4-ethoxyaniline (CAS 443741-71-7)
- Methyl 4-(((5-(((2,4-dichlorobenzyl)sulfinyl)methyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)methyl)benzoate (CAS 344272-17-9)
- N-(4-((2,4-dichlorobenzyl)thio)phenyl)-2-(4-phenylpiperazin-1-yl)acetamide (CAS 763107-10-4)
- 3-(((2,4-Dichlorobenzyl)thio)methyl)-5-((4-methylbenzyl)thio)-4-phenyl-4H-1,2,4-triazole (CAS 344274-60-8)
- 3-(((2,6-Dichlorobenzyl)thio)methyl)-5-((4-methylbenzyl)thio)-4-phenyl-4H-1,2,4-triazole (CAS 344271-41-6)
- 6-(2,4-Dichlorobenzyl)-2-(3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophen-2-yl)-5-methylpyrazolo[1,5-a]pyrimidin-7(1H)-one (CAS 439110-98-2)
- (E)-4-((3,4-dichlorobenzyl)oxy)-N'-((perfluorophenyl)methylene)benzohydrazide (CAS 303987-45-3)
Recommended Standards
- (2E)-3-{4-[(2,4-dichlorophenyl)methoxy]phenyl}-1-[4-(2-fluorophenyl)piperazin-1-yl]prop-2-en-1-one (CAS 477888-67-8)
- 2-(Naphthalen-2-yl)-4-phenyl-6-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1,3,5-triazine (CAS 2741917-59-7)
- 7-(4-Bromophenyl)-2-(4-(2-fluorophenyl)piperazin-1-yl)thieno[3,2-d]pyrimidin-4(1H)-one (CAS 1242861-55-7)
- N-Acetyllactosamine 6-Sulfate Sodium Salt (CAS 145447-78-5)
- N-(3-Bromophenyl)-3-nitrobenzamide (CAS 69754-51-4)
- N-(3-cyanofuro[3,2-b]pyridin-2-yl)-3-methoxybenzamide (CAS 672925-51-8)
- Pyridin-3-amine Hydrochloride (CAS 73074-20-1)
- 4,6-Dichloro-2-(4-nitrophenyl)pyrimidine (CAS 83217-23-6)
- 4-(3-Fluorophenyl)butan-1-ol (CAS 75906-34-2)
- 7-Bromo-2-(1-methyl-1H-pyrazol-4-yl)quinoxaline (CAS 1083325-87-4)
- 3-methoxyoxan-4-one (CAS 624734-17-4)
- Ixazomib Impurity 29 (CAS 1201903-03-8)
- 5-Bromo-4-iodo-6-(trifluoromethyl)pyridin-2-amine (CAS 2887439-61-2)
- Semaglutide Main Chain P29 (CAS 1169630-82-3)
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