Hydrochlorothiazide EP Impurity C CAS 402824-96-8
| CAS No. | 402824-96-8 |
| Molecular Formula | C15H16Cl2N6O8S4 |
| Molecular Weight | 607.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Hydrochlorothiazide EP Impurity C (CAS 402824-96-8) is a certified pharmaceutical impurity reference standard with the molecular formula C15H16Cl2N6O8S4 and a molecular weight of 607.49 g/mol.
The molecular framework of Hydrochlorothiazide EP Impurity C (C15H16Cl2N6O8S4) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H16Cl2N6O8S4 |
| Molecular Weight | 607.49 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 4 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity 28 (CAS CATO-C4X-117728)
- Hydrochlorothiazide Impurity 58 (CAS 289907-38-6)
- Hydrochlorothiazide Impurity 27 (CAS CATO-C4X-117727)
- Hydrochlorothiazide Impurity 30 (CAS CATO-C4X-117730)
- Hydrochlorothiazide Impurity 50 (CAS CATO-C4X-117750)
- Hydrochlorothiazide Impurity 26 (CAS CATO-C4X-117726)
- Hydrochlorothiazide Impurity 8 (CAS CATO-C4X-11778)
- Hydrochlorothiazide Impurity 39 (CAS CATO-C4X-117739)
Recommended Standards
- (Z)-(Bis(6-methylheptyl) stibenous) (Z)-4-((6-methylheptyl)oxy)-4-oxobut-2-enoic anhydride (CAS 71850-88-9)
- [(1,2,3-η)-2-Buten-1-yl]chloro[dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2-yl)phosphine-κP]palladium (CAS 1798781-99-3)
- Fosaprepitant Impurity 43 (CAS CATO-C4X-116843)
- 1,8-Bis((4-(2-hydroxyethoxy)phenyl)amino)anthracene-9,10-dione (CAS 16472-23-4)
- Iguratimod Impurity 122 HCl (CAS CATO-C4X-1826122)
- Tebipenem pivoxil Impurity P6 (CAS 1665289-91-7)
- Marbofloxacin EP Impurity A (CAS 115551-40-1)
- N-Octanoyl-DL-homoserine lactone (CAS 106983-30-6)
- N-(8-(Benzyloxy)-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 142979-40-6)
- 2-Bromo-5-((tert-butoxycarbonyl)amino)thiazole-4-carboxylic acid (CAS 1312697-86-1)
- Ethyl 2-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate (CAS 1648864-50-9)
- Cy3 NHS ester (CAS 1032678-38-8)
- Manool (80%) (CAS 596-85-0)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
Why CATO?
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