Hydrochlorothiazide Impurity 58 CAS 289907-38-6
| CAS No. | 289907-38-6 |
| Molecular Formula | C19H28ClN3O14S2 |
| Molecular Weight | 622.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C19H28ClN3O14S2, Hydrochlorothiazide Impurity 58 contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 622.02 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Hydrochlorothiazide Impurity 58 (CAS 289907-38-6, C19H28ClN3O14S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H28ClN3O14S2 |
| Molecular Weight | 622.02 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity 28 (CAS CATO-C4X-117728)
- Hydrochlorothiazide Impurity 27 (CAS CATO-C4X-117727)
- Hydrochlorothiazide EP Impurity C (CAS 402824-96-8)
- Hydrochlorothiazide Impurity 30 (CAS CATO-C4X-117730)
- Hydrochlorothiazide Impurity 50 (CAS CATO-C4X-117750)
- Hydrochlorothiazide Impurity 26 (CAS CATO-C4X-117726)
- Hydrochlorothiazide Impurity 8 (CAS CATO-C4X-11778)
- Hydrochlorothiazide Impurity 39 (CAS CATO-C4X-117739)
Recommended Standards
- 27888-44-4 C22 Ceramide (d18:1/22:0) (CAS 27888-44-4)
- Levothyroxine EP Impurity C (CAS 51-24-1)
- C22 Ceramide (CAS 869501-30-4)
- Liothyronine Impurity N1 (CAS 92151-30-9)
- Dobutamine Impurity 34 (CAS CATO-C4X-129834)
- Vidarabine Impurity 10 (CAS 26524-56-1)
- Flumetasone Impurity 15 (CAS CATO-C4X-191015)
- 5-Methoxycarbonyl-2,3-dihydro-1H-indole hydrochloride (CAS 1187928-10-4)
- Methyl 2-(4-hydroxy-2-methoxyphenyl)acetate (CAS 499789-92-3)
- 1,2,4-Triazin-5-amine (CAS 822-69-5)
- 2-Methyl-1-((4-nitrophenyl)sulfonyl)pyrrolidine (CAS 875930-44-2)
- 1-(3-(Benzo[d]oxazol-2-ylthio)propyl)-3-(thiazol-2-yl)urea (CAS 900009-38-3)
- 2’-Nitrophenyl 2,3-Di-O-acetyl-b-D-xylopyranoside (CAS 162088-91-7)
- Semaglutide Impurity 11 (CAS CATO-C4X-222611)
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