Fosaprepitant Impurity 43 CAS CATO-C4X-116843

Description

The occurrence of Fosaprepitant Impurity 43 is closely related to a steroid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

As a process- or degradation-related impurity, Fosaprepitant Impurity 43 (CAS CATO-C4X-116843, C27H25F7NO5P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Fosaprepitant Impurity 43 (C27H25F7NO5P) contains a steroid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Fosaprepitant Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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