Indometacin EP Impurity F CAS 402849-27-8
| CAS No. | 402849-27-8 |
| Molecular Formula | C21H16Cl2N2O3 |
| Molecular Weight | 415.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Indometacin EP Impurity F under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Indometacin EP Impurity F (CAS 402849-27-8) is a certified pharmaceutical impurity reference standard with the molecular formula C21H16Cl2N2O3 and a molecular weight of 415.27 g/mol.
Based on its molecular formula C21H16Cl2N2O3, Indometacin EP Impurity F contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 415.27 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H16Cl2N2O3 |
| Molecular Weight | 415.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Indometacin Standards
- Indometacin Impurity 19 (CAS CATO-C4X-147019)
- Indometacin Impurity 22 (CAS 78458-34-1)
- Indometacin Impurity 23 (CAS CATO-C4X-147023)
- Indometacin Impurity 31 (CAS CATO-C4X-147031)
- Indometacin Impurity 32 (CAS CATO-C4X-147032)
- Indometacin Impurity 33 (CAS CATO-C4X-147033)
- Indometacin Impurity 34 (CAS CATO-C4X-147034)
- Indometacin Impurity 21 (CAS 71848-87-8)
Recommended Standards
- (S)-2-(4-((3,4-dichlorobenzyl)oxy)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde (CAS 1246828-97-6)
- 4-(4-Bromophenyl)-2-{[2-(1H-indol-2-yl)ethyl]amino}-4-oxobutanoic acid (CAS 1024591-91-0)
- Lusutrombopag Impurity 23 (CAS CATO-C4X-208423)
- 1-(Tert-butyl) 3-methyl (3S,4S)-4-(5-bromo-3-methoxypyridin-2-yl)pyrrolidine-1,3-dicarboxylate (CAS 1217743-30-0)
- Sunitinib Impurity 15 (CAS 590424-05-8)
- Flomoxef Impurity 44 (CAS CATO-C4X-138244)
- Moxifloxacin Impurity 74 (CAS CATO-C4X-107474)
- 2-[(Piperazin-1-yl)methyl]benzonitrile (CAS 174609-74-6)
- 3-(3-Fluorobenzylidene)azetidine (CAS 1521916-55-1)
- 2,2'-Azanediyldiphenol (CAS 2391-71-1)
- 4-Cyclopropoxy-5-iodo-N-methylpyridin-3-amine (CAS 1243393-53-4)
- 2-(2-Cyano-6-fluoropyridin-4-yl)acetic acid (CAS 1393541-38-2)
- (R)-1-(3,5-Dimethoxyphenyl)propan-1-amine (CAS 1213087-13-8)
- D-Ile27-Tirzepatide (CAS CATO-CPTD788907)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com