Indometacin Impurity 22 CAS 78458-34-1
| CAS No. | 78458-34-1 |
| Molecular Formula | C22H22ClNO5 |
| Molecular Weight | 415.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Indometacin Impurity 22 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Indometacin Impurity 22 (CAS 78458-34-1) is a certified pharmaceutical impurity reference standard with the molecular formula C22H22ClNO5 and a molecular weight of 415.87 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Indometacin Impurity 22 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 415.87 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Indometacin Impurity 22 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H22ClNO5 |
| Molecular Weight | 415.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Indometacin Standards
- Indometacin Impurity 23 (CAS CATO-C4X-147023)
- Indometacin Impurity 31 (CAS CATO-C4X-147031)
- Indometacin Impurity 32 (CAS CATO-C4X-147032)
- Indometacin Impurity 33 (CAS CATO-C4X-147033)
- Indometacin Impurity 34 (CAS CATO-C4X-147034)
- Indometacin Impurity 19 (CAS CATO-C4X-147019)
- Indometacin EP Impurity F (CAS 402849-27-8)
- Indometacin Impurity 21 (CAS 71848-87-8)
Recommended Standards
- Isavuconazole Impurity 32 (CAS 338990-31-1)
- Dronedarone Impurity 23 (CAS CATO-C4X-109223)
- Prucalopride Impurity 41（DP-4） (CAS 1900715-95-8)
- 5-(2-Chloro-6-fluorobenzylidene)-2-(4-propoxyphenyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (CAS 618076-80-5)
- Acotiamide Impurity 33 (CAS 788137-01-9)
- Ceftazidime impurity 117 (CAS CATO-C4X-1212117)
- Cefcapene Impurity 20 (CAS CATO-C4X-182420)
- 1-Alanylpiperidine-3-carboxylic acid (CAS 1249683-43-9)
- 5-(3-Fluorophenyl)picolinic acid (CAS 1158763-55-3)
- Z-Ile-Bt (CAS 1072442-07-9)
- 4-Fluoro-N'-hydroxybenzimidamide (CAS 1164246-18-7)
- 3-{5h,6h,7h,8h-imidazo[1,5-a]pyridin-3-yl}aniline (CAS 1049130-67-7)
- Methyl 2-formyl-3,5-dihydroxybenzoate (CAS 16849-78-8)
- MLCK inhibitor peptide 18 (CAS 224579-74-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com