6-Fluoronicotinic Acid CAS 403-45-2
| CAS No. | 403-45-2 |
| Molecular Formula | C6H4FNO2 |
| Molecular Weight | 141.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Fluoronicotinic Acid.
6-Fluoronicotinic Acid (CAS 403-45-2), molecular formula C6H4FNO2 and molecular weight 141.10 g/mol, is a CATO reference standard with documented purity and traceability.
6-Fluoronicotinic Acid (C6H4FNO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4FNO2 |
| Molecular Weight | 141.10 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoronicotinic Standards
Recommended Standards
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- 1-Fluoro-3-nitrobenzene (CAS 402-67-5)
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- 2-Propenoic acid, 2-hydroxypropyl ester, homopolymer (CAS 32029-53-1)
- 6-Amino-4-bromo-5-(difluoromethyl)pyridine-3-sulfonamide (CAS 1805206-79-4)
- Cobalt(II) Acetate (CAS 944155-28-6)
- 5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-4-methyl-6-(methylsulfonyl)pyrimidine (CAS 1823182-68-8)
- Tranexamic Impurity 40 (CAS 2469781-80-2)
- 5-(2-bromo-3,5-dimethyl-3H-imidazol-4-yl)-3-methyl-[1,2,4]oxadiazole (CAS 436805-11-7)
- 2-(2-Chloropyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (CAS 724726-05-0)
- 3,3-Bis(((tert-butyldimethylsilyl)oxy)methyl)cyclobutan-1-amine (CAS 130369-34-5)
- Semaglutide impurity 93 (CAS CATO-C4X-222693)
Why CATO?
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