Nintedanib Impurity 59 CAS 350-46-9
| CAS No. | 350-46-9 |
| Molecular Formula | C6H4FNO2 |
| Molecular Weight | 141.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nintedanib Impurity 59 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Nintedanib Impurity 59 (CAS 350-46-9) is a certified pharmaceutical impurity reference standard with the molecular formula C6H4FNO2 and a molecular weight of 141.10 g/mol.
Based on its molecular formula C6H4FNO2, Nintedanib Impurity 59 contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 141.10 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C6H4FNO2 |
| Molecular Weight | 141.10 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 19 (CAS 1125-88-8)
- Nintedanib Impurity 73 (CAS 54699-92-2)
- Nintedanib Impurity 47 (CAS 119-63-1)
- Nintedanib Impurity 62 (CAS 34539-21-4)
- Nintedanib Impurity 68 (CAS 2840-28-0)
- Nintedanib Impurity 97 (CAS 637-98-9)
- Nintedanib Impurity 34 (CAS 334952-09-9)
- Nintedanib Impurity 160 (CAS 7207-35-4)
Recommended Standards
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- 5-fluoranyl-2-oxidanylidene-1H-pyridine-4-carbaldehyde 5-fluoro-2-oxo-1H-pyridine-4-carboxaldehyde 500148-38-9 A827933 (CAS 500148-38-9)
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- Topicamide lmpurity 7 (CAS CATO-C4X-21507)
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- 3-chloro-N-methylpropane-1-sulfonamide (CAS 83635-06-7)
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- alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol (CAS 107344-63-8)
- 6-[(3,4,4-Trifluorobut-3-en-1-yl)sulfanyl]-9H-purine (CAS 478067-83-3)
- 1-(4-Methoxyphenyl)cyclopropanol (CAS 15973-65-6)
- (1-Methyl-5-(morpholinomethyl)-1H-pyrrol-3-yl)(phenyl)methanone (CAS 866149-58-8)
- Ac-(5-31)Semaglutide (CAS CATO-C4X-2226279)
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