Josamycin EP Impurity B (18-Dihydroleucomycin A3) CAS 40361-41-9
| CAS No. | 40361-41-9 |
| Molecular Formula | C42H71NO15 |
| Molecular Weight | 830.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Josamycin EP Impurity B (18-Dihydroleucomycin A3) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Josamycin EP Impurity B (18-Dihydroleucomycin A3) (CAS 40361-41-9), a pharmacopoeial impurity reference standard (molecular formula C42H71NO15, MW 830.01 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Josamycin EP Impurity B (18-Dihydroleucomycin A3) is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 830.01 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C42H71NO15 |
| Molecular Weight | 830.01 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 1 |
Related Josamycin Standards
- Josamycin EP Impurity D (Isoleucomycin A3) (CAS 22340-94-9)
- Josamycin Impurity 8 (CAS CATO-C4X-30158)
- Josamycin Impurity 7 (CAS CATO-C4X-30157)
- Josamycin EP Impurity J (CAS CATO-C4X-301512)
- Josamycin EP Impurity E (Platenomycin A1) (CAS 40615-47-2)
- Josamycin EP Impurity A (CAS 18361-46-1)
- Josamycin EP Impurity K (CAS 18361-48-3)
- Josamycin EP Impurity H (KitasaMycin A1) (CAS 16846-34-7)
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Why CATO?
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