Nefopam Impurity 32 CAS CATO-C4X-283732
| CAS No. | CATO-C4X-283732 |
| Molecular Formula | C17H18BrNO2 |
| Molecular Weight | 348.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Nefopam Impurity 32 (CAS CATO-C4X-283732, C17H18BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nefopam Impurity 32 (C17H18BrNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18BrNO2 |
| Molecular Weight | 348.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Nefopam Standards
- Nefopam Impurity 31 (CAS CATO-C4X-283731)
- Nefopam Impurity 33 (CAS CATO-C4X-283733)
- Nefopam impurity 15 (CAS CATO-C4X-283715)
- Nefopam Impurity 6 (CAS 69984-25-4)
- Nefopam impurity 17 (CAS 82561-25-9)
- Nefopam impurity 16 (CAS CATO-C4X-283716)
- Nefopam Impurity 21 (CAS CATO-C4X-283721)
- Nefopam Impurity 4 (CAS 24833-47-4)
Recommended Standards
- N-(4-Bromophenyl)-4-(o-tolyloxy)butanamide (CAS 385373-45-5)
- Tert-butyl methyl(3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate (CAS 1032758-82-9)
- N-(2-bromophenyl)-2-(4-isopropylphenoxy)acetamide (CAS 431995-26-5)
- Tert-butyl ethyl(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate (CAS 1032758-86-3)
- Progesterone Impurity 41 (CAS 2477-60-3)
- Imatinib Impurity 82 (CAS CATO-C4X-106882)
- Saxagliptin Impurity 40 (CAS 361442-00-4)
- 6-Bromo-2,3-dihydro-imidazo[1,2-a]pyridine (CAS 793628-63-4)
- Penehyclidine impurity 18 (CAS CATO-C4X-130418)
- N-(2,6-Dimethylphenyl)-3-methoxyisoxazole-5-carboxamide (CAS 145441-09-4)
- 7-Chloro-1-(3-hydroxypropyl)-3,8-dimethylquinolin-2(1H)-one (CAS 2121050-52-8)
- 3-(4-Nitro-1H-pyrazol-1-yl)propanoic acid (CAS 512810-21-8)
- (4-Fluorophenyl)-(4-isopropoxyphenyl)-methanone (CAS 1097018-70-6)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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