Safinamide Impurity 33 CAS 405-85-6
| CAS No. | 405-85-6 |
| Molecular Formula | C14H11FO3 |
| Molecular Weight | 246.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 246.23 g/mol gives Safinamide Impurity 33 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Safinamide Impurity 33 (CAS 405-85-6) is a certified pharmaceutical impurity reference standard with the molecular formula C14H11FO3 and a molecular weight of 246.23 g/mol.
The molecular framework of Safinamide Impurity 33 (C14H11FO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11FO3 |
| Molecular Weight | 246.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Safinamide Standards
- Safinamide Impurity 63 (CAS CATO-C4X-159063)
- Safinamide Impurity 26 (CAS CATO-C4X-159026)
- Safinamide Impurity 5 (CAS 690969-16-5)
- Safinamide impurity 01 (CAS 1443302-79-1)
- Safinamide Impurity 18 (CAS 56442-17-2)
- Safinamide Impurity 19 (CAS 70627-20-2)
- Safinamide Impurity 21 (CAS 590353-54-1)
- Safinamide Impurity 44 (CAS 172685-67-5)
Recommended Standards
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- Pemirolast Impurity 8 (CAS CATO-C4X-24708)
- Sodium Cromoglicate Impurity 16 (CAS CATO-C4X-201116)
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- 5-(2-Fluorobenzyl)-2-phenylpyrimidine-4,6-diamine (CAS 338965-19-8)
- 3-methylbut-3-en-1-amine hydrochloride (CAS 17875-22-8)
- 1-Aminobenzimidazole (CAS 6299-92-9)
- 3-(2-chlorophenyl)-4-methyl-4H-1,2,4-triazole (CAS 168968-41-0)
- 5-(1-Isopropylpyrrolidin-2-yl)-2-methoxypyridine (CAS 1352489-34-9)
- {2-[(4-chlorophenyl)sulfanyl]pyridin-3-yl}methyl N-(propan-2-yl)carbamate (CAS 339278-52-3)
- Hexapeptide-10 (CAS 146439-94-3)
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