Isavuconazole Impurity 87 CAS 4072-67-7
| CAS No. | 4072-67-7 |
| Molecular Formula | C16H12Br2O2 |
| Molecular Weight | 396.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Isavuconazole Impurity 87 (C16H12Br2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Isavuconazole Impurity 87 (CAS 4072-67-7) is a certified pharmaceutical impurity reference standard with the molecular formula C16H12Br2O2 and a molecular weight of 396.07 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12Br2O2 |
| Molecular Weight | 396.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Br-containing |
Related Isavuconazole Standards
- Isavuconazole Impurity 139 (CAS CATO-C4X-1236139)
- Isavuconazole Impurity 49 (CAS CATO-C4X-123649)
- Isavuconazole Impurity 67 (CAS CATO-C4X-123667)
- Isavuconazole Impurity 32 (CAS 338990-31-1)
- Isavuconazole Impurity 198 (CAS CATO-C4X-1236198)
- Isavuconazole Impurity 219 (CAS CATO-C4X-1236219)
- Isavuconazole (CAS 241479-67-4)
- Isavuconazole Impurity 24 (CAS 1176988-44-5)
Recommended Standards
- 2-((9H-Fluoren-9-ylidene)methyl)furan (CAS 2871-88-7)
- 2,2,3,3,4,4,5,5,6,6,7,7,8,8-Tetradecafluorooctanoic acid (CAS 13973-14-3)
- 1,4-Bis(4-bromophenyl)-1,4-butanedione (CAS 2461-83-8)
- 1,1'-((2,5-Dibromo-1,4-phenylene)bis(methylene))bis(1H-imidazole) (CAS 2375720-18-4)
- Bupivacaine EP Impurity B Hydrochloride (CAS 65797-42-4)
- Ipratropium Bromide EP Impurity C (CAS 552-63-6)
- Argatroban Impurity 49 (CAS CATO-C4X-100749)
- (Cyclobutylmethyl)hydrazine hydrochloride (CAS 1986342-29-3)
- 2-methyl-5-(trifluoromethyl)morpholine (CAS 1375471-67-2)
- Crisaborole Impurity 147 (CAS CATO-C4X-202147)
- 3,5-Dichloro-4-methylanisole (CAS 1806346-58-6)
- Glipizide EP Impurity A (CAS 33288-71-0)
- 3-Chloro-4-hydroxy-n-(pyridin-3-ylmethyl)benzamide (CAS 1041525-50-1)
- Hexapeptide-9 (CAS 885024-94-2)
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