Rabeprazole Impurity 28 CAS 40828-54-4
| CAS No. | 40828-54-4 |
| Molecular Formula | C7H6N2O3S |
| Molecular Weight | 198.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rabeprazole Impurity 28 (CAS 40828-54-4, C7H6N2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rabeprazole Impurity 28 (C7H6N2O3S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 198.20 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6N2O3S |
| Molecular Weight | 198.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Rabeprazole Standards
- Rabeprazole Impurity 52 (CAS 209914-29-4)
- Rabeprazole impurity 48 (CAS 92288-14-7)
- Rabeprazole Impurity 23 (CAS 1260859-24-2)
- Rabeprazole Impurity 24 (CAS 118175-10-3)
- Rabeprazole Impurity 41 (CAS 117977-18-1)
- Rabeprazole Impurity 29 (CAS 1163685-31-1)
- Rabeprazole Impurity 35 (CAS 117977-20-5)
- Rabeprazole Impurity 40 (CAS 59886-90-7)
Recommended Standards
- N-methyl-5-nitroimidazo[2,1-b]thiazol-6-amine (CAS 339008-23-0)
- Dotinurad Impurity 67 (CAS 39884-80-5)
- Methyl isopropyl(phenyl)phosphinate (CAS 69423-58-1)
- Dimethyl Isophthalate-2,4,5,6-d4 (CAS 1007509-57-0)
- Meropenem Impurity 46 (CAS CATO-C4X-130946)
- ent-Cefradine EP Impurity B (CAS 26108-29-2)
- Desmopressin Impurity 28 (CAS CATO-C4X-221528)
- 2-Hexyl-2-methyl-4-phenyl-1,3-dioxolane (CAS 55668-45-6)
- Ethyl 3-(3-methyl-N-propylbenzamido)propanoate (CAS 1901944-93-1)
- 3-(1H-Benzo[d]imidazol-2-yl)propanenitrile (CAS 51100-82-4)
- Tert-butyl (3R,4R)-4-(aminomethyl)-3-fluoropiperidine-1-carboxylate (CAS 1932103-83-7)
- (S)-3-((2R,3S,5S)-5-Allyl-3-(benzyloxy)-4-oxotetrahydrofuran-2-yl)propane-1,2-diyl dibenzoate (CAS 871348-04-8)
- Methyl 2-amino-5,6,7,8-tetrahydroquinoline-3-carboxylate (CAS 67960-35-4)
- Peptide YY (13-36) (canine, mouse, porcine, rat) (CAS 86895-09-2)
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