Lenvatinib Impurity 109 CAS 417723-63-8
| CAS No. | 417723-63-8 |
| Molecular Formula | C12H11ClN2O2 |
| Molecular Weight | 250.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lenvatinib Impurity 109 (C12H11ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Lenvatinib Impurity 109 (CAS 417723-63-8), a pharmacopoeial impurity reference standard (molecular formula C12H11ClN2O2, MW 250.68 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11ClN2O2 |
| Molecular Weight | 250.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lenvatinib Standards
- Lenvatinib Impurity 144 (CAS CATO-C4X-1140144)
- Lenvatinib Impurity 140 (CAS CATO-C4X-1140140)
- Lenvatinib Impurity 18 (CAS 205448-66-4)
- Lenvatinib Impurity 80 (CAS CATO-C4X-114080)
- Lenvatinib Impurity 74 (CAS CATO-C4X-114074)
- Lenvatinib Impurity 82 (CAS CATO-C4X-114082)
- Lenvatinib Impurity 54 (CAS 2143930-77-0)
- Lenvatinib Impurity 160 (CAS CATO-C4X-1140160)
Recommended Standards
- Neratinib Impurity 52 (CAS CATO-C4X-113452)
- 1H-Pyrrolo[2,1-c][1,4]benzodiazepine-3,11(2H,11aH)-dione, 7-chloro-5,10-dihydro-, (11aR)- (CAS 1581274-42-1)
- 5-(2H-Tetrazol-5-yl)-2-thiophenesulfonyl chloride (CAS 924964-21-6)
- 1H-Pyrrolo[2,1-c][1,4]benzodiazepine-3,11(2H,11aH)-dione, 7-chloro-5,10-dihydro-, (11aS)- (CAS 1581274-41-0)
- Thiocolchicoside EP Impurity K (CAS CATO-C4X-27703)
- LCZ-696 Impurity 32 (CAS CATO-C4X-169632)
- Orforglipron impurity 135 (CAS 2384281-38-1)
- BKT140 (CAS 664334-36-5)
- 2-Chloro-7-(trifluoromethyl)quinazoline (CAS 1388043-95-5)
- 7-(3-Chlorobenzyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one (CAS 1361003-90-8)
- 5-Bromo-4-chloro-2-methylphenol (CAS 1780721-85-8)
- 7-(1,3-benzodioxol-5-yl)-2-(4-cyanophenyl)[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (CAS 860650-35-7)
- 1-(Oxazolo[4,5-b]pyridin-2-yl)dodecan-1-one (CAS 288862-73-7)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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