Avanafil Impurity 54 CAS 41965-95-1
| CAS No. | 41965-95-1 |
| Molecular Formula | C8H10ClNO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Avanafil Impurity 54 is closely related to an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Avanafil Impurity 54 (CAS 41965-95-1), a pharmacopoeial impurity reference standard (molecular formula C8H10ClNOHCl, MW 208.08 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Avanafil Impurity 54 (C8H10ClNOHCl) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 208.08 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10ClNO HCl |
| Molecular Weight | 208.08 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Avanafil Standards
- Avanafil Impurity 77 (CAS 1201936-61-9)
- Avanafil Impurity 160 (CAS 1202002-16-1)
- Avanafil Impurity 3 (CAS 1364671-52-2)
- Avanafil Impurity 2 (CAS 1364671-62-4)
- Avanafil Impurity 110 (CAS 1368440-33-8)
- Avanafil Impurity 4 (CAS 1452128-53-8)
- Avanafil Impurity 133 (CAS 1508194-63-5)
- Avanafil Impurity 46 (CAS 1624833-89-1)
Recommended Standards
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- Ethyl (1S,2R)-2-benzylcyclopropane-1-carboxylate (CAS 1680198-25-7)
- 3-Amino-4-(trifluoromethoxy)benzonitrile (CAS 1220630-86-3)
- 1-Bromodecane-10,10,10-d3 (CAS 284474-47-1)
- Oseltamivir impurity 265 Phosphate (CAS 1035895-88-5)
- 1-(2-Bromo-4-(difluoromethyl)phenyl)piperidin-4-ol (CAS 1704073-27-7)
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- (Glu1)-Fibrinopeptide B (human) (CAS 103213-49-6)
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