Avanafil Impurity 3 CAS 1364671-52-2
| CAS No. | 1364671-52-2 |
| Molecular Formula | C19H19ClN6O3S |
| Molecular Weight | 446.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Avanafil Impurity 3.
Avanafil Impurity 3 (CAS 1364671-52-2) is a certified pharmaceutical impurity reference standard with the molecular formula C19H19ClN6O3S and a molecular weight of 446.91 g/mol.
The molecular framework of Avanafil Impurity 3 (C19H19ClN6O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Avanafil Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H19ClN6O3S |
| Molecular Weight | 446.91 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Avanafil Standards
- Avanafil Impurity 155 (CAS CATO-C4X-1118155)
- Avanafil Impurity 104 (CAS CATO-C4X-1118104)
- Avanafil Impurity 148 (CAS CATO-C4X-1118148)
- Avanafil Impurity 6 (CAS 330784-50-4)
- Avanafil Impurity 130 (CAS CATO-C4X-1118130)
- Avanafil Impurity 63 (CAS CATO-C4X-111863)
- Avanafil Impurity 21 (CAS CATO-C4X-111821)
- Avanafil Impurity 113 (CAS CATO-C4X-1118113)
Recommended Standards
- Diisopropyl (3-chloro-6-methyl-4-(p-tolylamino)quinolin-2-yl)phosphonate (CAS 326008-30-4)
- 4,6-Dibromo-2-(2-bromophenyl)benzo[d]oxazol-5-amine (CAS 637302-91-1)
- 3-(3-Chlorobenzo[b]thiophene-2-carboxamido)-N-phenylbenzofuran-2-carboxamide (CAS 620581-66-0)
- 4,6-Dibromo-2-(3-bromophenyl)benzo[d]oxazol-5-amine (CAS 637302-92-2)
- Folic Acid Impurity 14 (CAS 4033-27-6)
- Relugolix Impurity 112 (CAS 1589503-94-5)
- Daptomycin Impurity 62 (CAS CATO-C4X-137862)
- 914111-18-5 Polygalatenoside A (CAS 914111-18-5)
- 3-((2-(4-Chlorophenoxy)ethyl)thio)-N5,N7-diethyl-[1,2,4]triazolo[4,3-a][1,3,5]triazine-5,7-diamine (CAS 849124-92-1)
- 1-(Quinoxalin-6-yl)ethanamine (CAS 1073429-20-5)
- 4-Ethyl-3-(furan-2-yl)-5-((4-methoxybenzyl)thio)-4H-1,2,4-triazole (CAS 577790-47-7)
- 2-pyrrol-1-ylacetic acid (CAS 19167-98-7)
- Methyl [2,3'-bipyridine]-4-carboxylate, 97% (CAS 579476-58-7)
- Semaglutide Impurity 192 (CAS CATO-C4X-2226192)
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