N-(2-Chloro-4-iodophenyl)-4-methylbenzamide CAS 424815-38-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2-Chloro-4-iodophenyl)-4-methylbenzamide.

N-(2-Chloro-4-iodophenyl)-4-methylbenzamide (CAS 424815-38-3), molecular formula C14H11ClINO and molecular weight 371.60 g/mol, is a CATO reference standard with documented purity and traceability.

N-(2-Chloro-4-iodophenyl)-4-methylbenzamide (C14H11ClINO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/iodine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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