Doxapram Impurity 1 (2-Ketodoxapram) CAS 42595-88-0
| CAS No. | 42595-88-0 |
| Molecular Formula | C24H28N2O3 |
| Molecular Weight | 392.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Doxapram Impurity 1 (2-Ketodoxapram) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 392.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Doxapram Impurity 1 (2-Ketodoxapram) (CAS 42595-88-0, C24H28N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Doxapram Impurity 1 (2-Ketodoxapram) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H28N2O3 |
| Molecular Weight | 392.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Nitrogen Atoms | 2 |
Related Doxapram Standards
- Doxapram Impurity 14 (CAS CATO-C4X-197314)
- Doxapram N-Oxide (CAS CATO-C4X-197312)
- Doxapram Impurity 22 (CAS CATO-C4X-197322)
- Doxapram Impurity 32 (CAS CATO-C4X-197332)
- Doxapram Impurity 33 (CAS CATO-C4X-197333)
- Doxapram (CAS 309-29-5)
- Doxapram Impurity 10 (CAS 3192-92-5)
- Doxapram Impurity 31 (CAS 1415394-56-7)
Recommended Standards
- Indacaterol (CAS 312753-06-3)
- Naftopidil (CAS 57149-07-2)
- Indacaterol Impurity 39 (CAS CATO-C4X-150039)
- Cabergoline Impurity 7 (CAS CATO-C4X-27747)
- Abemaciclib Impurity 89 (CAS CATO-C4X-293789)
- Lacosamide EP Impurity J (CAS 100-46-9)
- Cycloserine Impurity 14 (CAS 19519-75-6)
- Canrenoic Acid (CAS 4138-96-9)
- (4E)-4-{[(4-methylpyrimidin-2-yl)amino]methylidene}-2-phenyl-4,5-dihydro-1,3-oxazol-5-one (CAS 339010-31-0)
- 1,3-Isobenzofurandione, 4,4'-[(1-methylethylidene)bis(4,1-phenyleneoxy)]bis-, polymer with 1,3-benzenediamine (CAS 61594-32-9)
- Selank (CAS 129954-34-3)
- (S)-3-(1-Carboxy-3-methylbutyl)-1-mesityl-1H-imidazol-3-ium hexafluorophosphate(V) (CAS 1788856-37-0)
- 5-Bromo-1-butyl-3-hydroxy-3-phenylindolin-2-one (CAS 866008-01-7)
- Semaglutide impurity 29 (CAS 110990-08-4)
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