Desmethyl Fluorometholone CAS 426-20-0
| CAS No. | 426-20-0 |
| Molecular Formula | C21H27FO4 |
| Molecular Weight | 362.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Desmethyl Fluorometholone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Desmethyl Fluorometholone (CAS 426-20-0), a pharmacopoeial impurity reference standard (molecular formula C21H27FO4, MW 362.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution, Desmethyl Fluorometholone is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 362.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H27FO4 |
| Molecular Weight | 362.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Desmethyl Standards
- 7-Desmethyl-9-(5-oxohexyl) Pentoxifylline (CAS 1329834-21-0)
- 3-Desmethyl-3-(5-oxohexyl) Pentoxifylline (CAS 1329835-59-7)
- N-Desmethyl Tamoxifen-d5 (CAS 164365-16-6)
- Desmethyl Boc-Cyclobenzaprine (CAS 1346604-04-3)
- 4-O-Desmethyl 4-O-benzyl trimethoprim, >98% (CAS 21822-34-4)
- Desmethyl Metsulfuron-methyl (CAS 126312-31-0)
- N-Desmethyl Prochlorperazine-d8 Dimaleate (CAS 1246817-68-4)
- N-Desmethyl Eletriptan (CAS 153525-55-4)
Recommended Standards
- Raloxifene Impurity 3 (CAS 1677681-02-5)
- Bilastine impurity 105 (CAS 2052955-68-5)
- Betamethasone impurity 73 (CAS 1203841-43-3)
- BRD-8899 (CAS 1404437-50-8)
- Biapenem impurity 17 (CAS CATO-C4X-227317)
- Rosuvastatin Impurity 89 (CAS CATO-C4X-116989)
- Mirogabalin Impurity 145 (CAS CATO-C4X-2924145)
- 1-Ethynyl-5-methylpyrimidine-2,4(1H,3H)-dione (CAS 141299-25-4)
- Ethyl 5-fluoropicolinate (CAS 148541-70-2)
- Afatinib Impurity 75 (CAS CATO-C4X-100675)
- Butyl O-Butyryllactate (CAS 7492-70-8)
- 2-Fluoro-3,6-dimethoxybenzoic acid (CAS 1352306-34-3)
- N-Ethyl-(2-thienylmethyl)amine (CAS 58255-25-7)
- Cholecystokinin Octapeptide (desulfated) (CAS 25679-24-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com