Afatinib Impurity 75 CAS CATO-C4X-100675
| CAS No. | CATO-C4X-100675 |
| Molecular Formula | C11H15ClN4 |
| Molecular Weight | 238.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Afatinib Impurity 75 (CAS CATO-C4X-100675, C11H15ClN4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C11H15ClN4, Afatinib Impurity 75 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 238.72 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Afatinib Impurity 75 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H15ClN4 |
| Molecular Weight | 238.72 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib Impurity 74 (CAS CATO-C4X-100674)
- Afatinib Impurity 72 (CAS 487060-47-9)
- Afatinib Impurity 88 (CAS 2475095-43-1)
- Afatinib Impurity 64 (CAS CATO-C4X-100664)
- Afatinib impurity 86 (CAS CATO-C4X-100686)
- Afatinib Impurity 28 (CAS 17519-02-7)
- Afatinib Impurity 50 (CAS 137131-09-0)
- Afatinib Impurity 35 (CAS 6943-17-5)
Recommended Standards
- 6-chloro-1-hexyl-1H-pyrazolo[3,4-d]pyrimidine (CAS 2711002-60-5)
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- 5-Chloro-N-pentylimidazo[1,2-a]pyrimidin-7-amine (CAS 89099-85-4)
- (4-Chloro-3-methylthiophen-2-yl)(phenyl)methanol (CAS 1443326-91-7)
- Dexmedetomidine Impurity 22 (CAS CATO-C4X-123022)
- Ambroxol impurity 68 (CAS 105735-86-2)
- Isoconazole nitrate EP Impurity C (CAS 22832-87-7)
- Methyl 1-Boc-3-methylpiperidine-3-carboxylate (CAS 888952-55-4)
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- Cp-154526 (CAS 157286-86-7)
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