Topiroxostat Impurity 48 CAS 4329-75-3
| CAS No. | 4329-75-3 |
| Molecular Formula | C12H10N4O2 |
| Molecular Weight | 242.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Topiroxostat Impurity 48.
Topiroxostat Impurity 48 (CAS 4329-75-3) is a certified pharmaceutical impurity reference standard with the molecular formula C12H10N4O2 and a molecular weight of 242.23 g/mol.
Structurally, Topiroxostat Impurity 48 (C12H10N4O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 242.23 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Topiroxostat Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10N4O2 |
| Molecular Weight | 242.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 4 |
Related Topiroxostat Standards
- Topiroxostat Impurity 63 (CAS 445218-61-1)
- Topiroxostat Impurity 20 (CAS CATO-C4X-105520)
- Topiroxostat Impurity 8 (CAS 36770-53-3)
- Topiroxostat Impurity 40 (CAS 4923-06-2)
- Topiroxostat Impurity 19 (CAS 38634-05-8)
- Topiroxostat Impurity 25 (CAS 31599-25-4)
- Topiroxostat Impurity N1 (CAS 14478-73-0)
- Topiroxostat Impurity 39 (CAS 57654-36-1)
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- Chromane-3-carboximidamide (CAS 1485005-45-5)
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- 2-(tert-Butylthio)-5-(1-methylpyrrolidin-2-yl)pyridine (CAS 1352533-27-7)
- 8-(Chloromethyl)imidazo[1,2-a]pyridine (CAS 167883-99-0)
- 3-(4-Fluoro-2-methylphenyl)pyrrolidine (CAS 1249000-99-4)
- Pyridoxine Impurity 19 DiHCl (CAS CATO-C4X-187747)
- Acetyl tetrapeptide-9(Dermican LS 9837) (CAS 928006-50-2)
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