2-Chloro-3-(4-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl}piperidin-1-yl)-1,4-dihydronaphthalene-1,4-dione CAS 439108-72-2
| CAS No. | 439108-72-2 |
| Molecular Formula | C26H23Cl2F3N4O3 |
| Molecular Weight | 567.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Chloro-3-(4-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl}piperidin-1-yl)-1,4-dihydronaphthalene-1,4-dione (CAS 439108-72-2), a certified reference material (molecular formula C26H23Cl2F3N4O3, MW 567.39 g/mol) for analytical method development and quality control.
2-Chloro-3-(4-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl}piperidin-1-yl)-1,4-dihydronaphthalene-1,4-dione (C26H23Cl2F3N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-3-(4-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl}piperidin-1-yl)-1,4-dihydronaphthalene-1,4-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H23Cl2F3N4O3 |
| Molecular Weight | 567.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 3-Chloro-2-[(1E)-[(E)-2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](phenyl)methylidene}hydrazin-1-ylidene](phenyl)methyl]-5-(trifluoromethyl)pyridine (CAS 339106-99-9)
- 4-Chloro-N-{1-[4-methyl-5-({[4-(trifluoromethyl)phenyl]methyl}sulfanyl)-4H-1,2,4-triazol-3-yl]-2-phenylethyl}benzene-1-sulfonamide (CAS 338794-29-9)
- 2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-4-(1,3-dioxo-2,3-dihydro-1H-inden-2-ylidene)-6-(pyridin-2-yl)-octahydropyrrolo[3,4-c]pyrrole-1,3-dione (CAS 321392-07-8)
- 4-Chloro-N-[1-(5-{[(3,4-dichlorophenyl)methyl]sulfanyl}-4-methyl-4H-1,2,4-triazol-3-yl)-2-phenylethyl]benzene-1-sulfonamide (CAS 338794-28-8)
- (3E)-5-Chloro-3-{2-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazin-1-ylidene}-1-{[3-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-1H-indol-2-one (CAS 303984-79-4)
- 2-((4-Chloro-N-(2,4-dichloro-5-methoxyphenyl)phenyl)sulfonamido)-N-(2,3-dichlorophenyl)acetamide (CAS 338961-57-2)
- 3-Chloro-N-(4-chloro-2-((5-chloropyridin-2-yl)carbamoyl)-6-methoxyphenyl)-4-((2-(methylamino)-1H-imidazol-1-yl)methyl)thiophene-2-carboxamide (CAS 229336-92-9)
- 3-Benzyl-8-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-chlorophenyl)-1-oxa-4,8-diazaspiro[4.5]Decane-4-carboxamide (CAS 338963-08-9)
Recommended Standards
- 2,4,6-Triiodo-1,3,5-triazine (CAS 5637-87-6)
- AZD-4818, >98% (HPLC) (CAS 1003566-93-5)
- O-{5-(2,4-dichlorophenoxy)-6-methyl-2-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl} O,O-diethyl phosphothioate (CAS 263869-08-5)
- Ibrutinib Impurity 63 (CAS CATO-C4X-106463)
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- Cyclazosin (CAS 139953-73-4)
- 3-Methyladamantan-1-ol (CAS 702-81-8)
- 2-Methylthiazolo[4,5-f]quinoxaline (CAS 114382-32-0)
- Sertraline EP Impurity A HCl (1R,4S-Isomer) (CAS 79896-32-5)
- 4-(Benzylamino)-2-chloronicotinonitrile (CAS 87243-49-0)
- Ribavirin Impurity 50 (CAS 13035-61-5)
- 1-(5-((4-Chlorophenyl)carbamoyl)-1,3,4-thiadiazole-2-carbonyl)piperidine-3-carboxylic acid (CAS 1142210-08-9)
- Tris(2-ethylhexyl) 2,2',2''-((methylstannanetriyl)tris(sulfanediyl))triacetate (CAS 57583-34-3)
- Mast Cell Degranulating (MCD) Peptide (CAS 32908-73-9)
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