Ibrutinib Impurity 63 CAS CATO-C4X-106463
| CAS No. | CATO-C4X-106463 |
| Molecular Formula | C28H28Cl2N6O3 |
| Molecular Weight | 567.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ibrutinib Impurity 63.
Ibrutinib Impurity 63 (CAS CATO-C4X-106463) is a certified pharmaceutical impurity reference standard with the molecular formula C28H28Cl2N6O3 and a molecular weight of 567.47 g/mol.
Ibrutinib Impurity 63 (C28H28Cl2N6O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ibrutinib Impurity 63 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C28H28Cl2N6O3 |
| Molecular Weight | 567.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 64 (CAS CATO-C4X-106464)
- Ibrutinib Impurity 28 (CAS CATO-C4X-106428)
- Ibrutinib Impurity 22 (CAS CATO-C4X-106422)
- Ibrutinib Impurity 118 (CAS CATO-C4X-1064118)
- Ibrutinib Impurity 111 (CAS CATO-C4X-1064111)
- Ibrutinib Impurity 91 (CAS CATO-C4X-106491)
- Ibrutinib Impurity 112 (CAS CATO-C4X-1064112)
- Ibrutinib Impurity 115 (CAS CATO-C4X-1064115)
Recommended Standards
- AZD-4818, >98% (HPLC) (CAS 1003566-93-5)
- 2-Chloro-3-(4-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl}piperidin-1-yl)-1,4-dihydronaphthalene-1,4-dione (CAS 439108-72-2)
- (2S)-2-[[(2S)-2-Amino-3-[3-[Bis(2-Chloroethyl)Amino]Phenyl]Propanoyl]-[(2S)-Pyrrolidine-2-Carbonyl]Amino]-3-(4-Fluorophenyl)Propanoic Acid (CAS 38305-84-9)
- 2,4,6-Triiodo-1,3,5-triazine (CAS 5637-87-6)
- Darolutamide impurity 4 (CAS 1297537-41-7)
- 7-ACA Impurity 3 (CAS CATO-C4X-23123)
- Ertapenem Impurity 24 (CAS CATO-C4X-163324)
- N-Boc-L-phenylalanine Ethyl Ester (CAS 53588-99-1)
- 3,6-Dimethylhept-1-yn-3-ol (CAS 19549-98-5)
- Ly2795050 (CAS 1346133-08-1)
- 2-Vinyltetrahydro-2H-pyran-3-carboxylic acid (CAS 1864053-58-6)
- Ethyl 2-amino-4-(2,4-dichlorophenyl)-5-oxo-4H,5H-thiochromeno[4,3-b]pyran-3-carboxylate (CAS 923551-49-9)
- 5-Propylpyrimidine (CAS 25255-26-9)
- Liraglutide (CAS 204656-20-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com