Sodium Valproate Impurity 23 CAS 4443-26-9
| CAS No. | 4443-26-9 |
| Molecular Formula | C14H15NO4 |
| Molecular Weight | 261.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Sodium Valproate Impurity 23 (CAS 4443-26-9, C14H15NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Sodium Valproate Impurity 23 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 261.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15NO4 |
| Molecular Weight | 261.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Sodium Standards
- Sodium Valproate Impurity 41 (CAS CATO-C4X-116641)
- Valproate Impurity 76 (CAS 502850-33-1)
- Valproate Impurity 85 (CAS CATO-C4X-116685)
- Valproate impurity 89 (CAS CATO-C4X-116689)
- Valproate Impurity 98 (CAS CATO-C4X-116698)
- Sodium Valproate Impurity 40 (CAS CATO-C4X-116640)
- Valproate Impurity 37 (CAS 62391-98-4)
- Valproate Impurity 47 (CAS 6065-63-0)
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- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-pyrrole-2-carbothioamide (CAS 400080-85-5)
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