8-(2,6-Difluorophenyl)-2-((1,3-dihydroxypropan-2-yl)amino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one CAS 444606-18-2
| CAS No. | 444606-18-2 |
| Molecular Formula | C23H19F3N4O3 |
| Molecular Weight | 456.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
8-(2,6-Difluorophenyl)-2-((1,3-dihydroxypropan-2-yl)amino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one (CAS 444606-18-2) is a high-purity analytical reference standard with the molecular formula C23H19F3N4O3 and a molecular weight of 456.42 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 8-(2,6-Difluorophenyl)-2-((1,3-dihydroxypropan-2-yl)amino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 456.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H19F3N4O3 |
| Molecular Weight | 456.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Difluorophenyl Standards
- (R)-8-[1-[(3,5-Difluorophenyl)amino]ethyl]-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (CAS 1627494-13-6)
- (Z)-2-((2,5-difluorophenyl)sulfonyl)-1-(4-ethylphenyl)-3-((4-methoxyphenyl)amino)prop-2-en-1-one (CAS 1327176-90-8)
- N-(2,4-difluorophenyl)-4-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide (CAS 338397-01-6)
- N-(2,4-Difluorophenyl)-2-{[4-({[(2,4-difluorophenyl)carbamoyl]methyl}sulfanyl)butyl]sulfanyl}acetamide (CAS 301194-29-6)
- 1-(2,4-Difluorophenyl)-7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 182869-17-6)
- 1-(2,4-Difluorophenyl)-7-(4-ethylpiperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 182869-19-8)
- 5-{bis[(3,4-difluorophenyl)methyl]amino}-1-(4-methylphenyl)-1H-pyrazole-4-carbonitrile (CAS 957040-67-4)
- 1-(2,4-Difluorophenyl)-6-oxo-4-(trifluoromethyl)-N-(4-(trifluoromethyl)phenyl)-1,6-dihydropyridazine-3-carboxamide (CAS 477859-68-0)
Recommended Standards
- TMP195, 98% (CAS 1314891-22-9)
- 2,2′-Bis[4-(trifluoromethyl)phenyl]-5,5′-bithiazole (CAS 869896-76-4)
- N-Nitroso Cariprazine (CAS CATO-C4X-24085)
- N-(4-Chloro-2-methylphenyl)-2-((5-((4-chlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)thio)acetamide (CAS 476484-63-6)
- 3-bromo-5-chlorofuro[3,2-b]pyridine (CAS 220939-68-4)
- 2-Amino-6-chloro-5-(difluoromethyl)nicotinaldehyde (CAS 1805100-39-3)
- (4-Chlorophenyl)biguanide (CAS 5304-59-6)
- 2-(Diethylamino)-3-(2-methylprop-1-en-1-yl)quinolin-4(1H)-one (CAS 88960-26-3)
- Lemborexant Impurity 22 (CAS 1369765-96-7)
- 3-(3-Acetyl-4-hydroxybenzylidene)dihydrofuran-2(3H)-one (CAS 91903-43-4)
- (Octyloxy)benzene (CAS 1818-07-1)
- 4-Chloro-6-(4-fluorophenoxy)-3-phenylpyridazine (CAS 477872-35-8)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(dimethylamino)methylidene]-2,2-difluoroacetamide (CAS 1823194-67-7)
- Semaglutide Impurity 128 (CAS 2490269-78-6)
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