Vardenafil Impurity N1 CAS 448184-56-3
| CAS No. | 448184-56-3 |
| Molecular Formula | C21H26N6O7S |
| Molecular Weight | 506.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Vardenafil Impurity N1 (CAS 448184-56-3) is a certified pharmaceutical impurity reference standard with the molecular formula C21H26N6O7S and a molecular weight of 506.53 g/mol.
The molecular framework of Vardenafil Impurity N1 (C21H26N6O7S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H26N6O7S |
| Molecular Weight | 506.53 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Vardenafil Standards
- Vardenafil Impurity 33 (CAS CATO-C4X-101733)
- Vardenafil Impurity 3 (CAS 224785-98-2)
- Vardenafil USP Related Compound D (CAS 448184-48-3)
- Vardenafil Impurity 38 (CAS 224787-06-8)
- Vardenafil Impurity 41 (CAS CATO-C4X-101741)
- Vardenafil Impurity 42 (CAS CATO-C4X-101742)
- Vardenafil Impurity 40 (CAS CATO-C4X-101740)
- Vardenafil Impurity 43 (CAS CATO-C4X-101743)
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